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Cat. No.: HY-122903S

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TK216-d₄

고객리뷰

Based on 1 Customer Validation

TK216-d₄ is the deuterium labeled TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor. TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 98.52%
CAS No.: 3034816-36-6
화학식: C₁₉H₁₁D₄Cl₂NO₃
분자량:380.26

보관:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

TK216-d₄ Chemical Structure

CAS No.: 3034816-36-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- 신청
Chemical Information
순도&문서
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

TK216-d₄ is the deuterium labeled TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor^[1]. TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity^[2].

IC₅₀ & Target

Helicase

All DNA/RNA Synthesis Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

신청

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 3034816-36-6
Unlabeled Cas 1903783-48-1
Appearance Solid
분자량 380.26
화학식 C₁₉H₁₁D₄Cl₂NO₃
Color White to off-white
SMILES

O=C1NC2=C(C1(O)CC(C3=C([2H])C([2H])=C(C([2H])=C3[2H])C4CC4)=O)C(Cl)=CC=C2Cl
선적

Room temperature in continental US; may vary elsewhere.