trans-AzoTAB

Trans-AzoTAB (1-100 μM; ≥3 min) inhibits voltage-gated peak sodium currents in isolated neonatal rat ventricular myocytes in a concentration-dependent manner, with an EC₅₀ of 60 μM, and reduces the current density by approximately 60% at 100 μM^[1].
Trans-AzoTAB (100 μM; ≥3 min) inhibits L-type voltage-gated calcium currents in isolated neonatal rat ventricular myocytes by approximately 60%, and this inhibitory effect is reversible via near-ultraviolet light-induced isomerization of Trans-AzoTAB to cis-AzoTAB^[1].
Trans-AzoTAB (100 μM; ≥3 min) increases the voltage-gated steady-state potassium current in isolated neonatal rat ventricular myocytes to approximately 145% of the control level, and this enhancing effect is reversible via near-ultraviolet light-induced isomerization of Trans-AzoTAB to cis-AzoTAB^[1].
trans-AzoTAB (0.0-2.0 mM) induces end-grafted λ-phage DNA to form a frozen surface-adsorbed conformation at concentrations ≥0.3 mM; its lateral extension continuously increases before reaching the freezing threshold, remains stable in the intermediate concentration range, and decreases at concentrations ≥0.8 mM^[2].
trans-AzoTAB (0.0-3.0 mM; 20 min) reversibly regulates the transcriptional activity of T4 genomic DNA with *E. coli* RNA polymerase and DNA conformation in a light-dependent manner; under dark conditions, it completely inhibits transcription at concentrations ≥2.0 mM, and up to 80% of the activity can be restored after 10 min of irradiation with 365 nm ultraviolet light^[3].
trans-AzoTAB (0.0-3.0 mM; 20 min) enables reversible regulation of the transcriptional activity of a 5 kb linearized plasmid carrying T7 RNA polymerase via light; transcriptional activity is completely inhibited at concentrations ≥2.0 mM under dark conditions, and after 10 min of irradiation with 365 nm ultraviolet light, transcriptional activity recovers to exceed the control level without altering the nature of the transcript^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.