Trioxacarcin B
Trioxacarcin B (TXN-B) is a potent cytotoxic agent and DNA-targeted inhibitor. Trioxacarcin B disrupts DNA function and induces apoptosis in cancer cells. Trioxacarcin B not only effectively inhibits the growth of various Gram-positive and Gram-negative bacteria as well as Plasmodium falciparum, but also blocks the colony formation of cancer stem cells, significantly reduces tumor volume and prolongs survival in preclinical in vivo models. The activity of Trioxacarcin B is highly dependent on its intact spiro-epoxide structure; it loses efficacy once this moiety undergoes hydrolysis, and Trioxacarcin B shows no activity against fungi, microalgae and small RNA viruses. Trioxacarcin B can be used for research on bacterial infections, malaria, and various cancers including colon cancer and melanoma.
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- CAS No.: 81534-36-3
- 화학식: C42H54O21
- 분자량:894.87
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
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Plasmodium |
Trioxacarcin B (30~40 μg; 9 mm culture dish) exhibits in vitro antimicrobial activity against Bacillus subtilis, Escherichia coli, Staphylococcus aureus, and Streptomyces viridochromogenes Tu 57; the diameters of the inhibition zones are 38 mm, 32 mm, 22 mm, and 27 mm, respectively[2].
Trioxacarcin B exhibits in vitro inhibitory activity against Plasmodium falciparum strains K1 and NF54, with mean IC50 values of 102 ng/mL and 82 ng/mL, respectively, following 24 h of treatment[2].
Trioxacarcin B exhibits in vitro antitumor activity against a panel of permanent human tumor cell lines, with a mean IC50 of 1.107 μg/mL and a mean IC70 of 2.161 μg/mL, and its activity varies across different cell lines[2].
Trioxacarcin B inhibits the colony formation of tumor stem cells derived from LXFL 529 large cell lung cancer xenografts in vitro, with an IC50 of 6.0 ng/mL, an IC70 of 25.0 ng/mL, and an IC90 of 157.0 ng/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT-29, SF-268, H-460, LXFA 526L, LXFL 529L, MCF-7, MEXF 514L, PC3M, and RXF 631L cell lines
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Concentration:IC70
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Incubation Time:24 h
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Result:The IC70 values for the HT-29, SF-268, H-460, LXFA 526L, LXFL 529L, MCF-7, MEXF 514L, PC3M, and RXF 631L cell lines were 6.463, 1.477, 1.47, 2.476, 0.609, 1.314, 5.756, >3.0, and 2.146 μg/ml, respectively.
The mean IC50 was 1.107 μg/ml, and the mean IC70 was 2.161 μg/ml.
Chemical Information
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CAS No. 81534-36-3
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분자량 894.87
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화학식 C42H54O21
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SMILES
CC1=C(C(O2)=C3C(C(OC)=C4C(C([C@H](C[C@@H]4O[C@H]5C[C@@](O)([C@@H]([C@@H](O5)C)OC(C)=O)C)O)=O)=C3O)=C1)[C@@](O[C@]([C@]6(O)CO)(O7)C(OC)OC)([H])[C@@]7([H])[C@@]26O[C@H]8C[C@H]([C@](O)([C@@H](O8)C)C(C)=O)O
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Synonyms
TXN-B
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Trioxacarcin B Related Classifications
HY-126929 Related Classifications
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- Trioxacarcin B
- 81534-36-3
- TXN-B
- DNA Alkylator/Crosslinker
- Apoptosis
- Bacterial
- Parasite
- Fungal
- Gram-negative bacteria
- Plasmodium falciparum
- human tumor cell lines
- tumor stem cells
- double-stranded DNA
- Staphylococcus aureus
- Gram-positive bacteria
- DNA guanine nucleobases
- Bacillus subtilis
- Escherichia coli
- Inhibitor
- inhibitor
- inhibit