U-99363E
U-99363E is a selective dopamine D4 receptor antagonist with a Ki value of 2.2 nM. U-99363E exhibits at least 100-fold lower affinity for other dopaminergic, serotonergic and adrenergic receptors. U-99363E can be used in studies related to selective dopamine D4 site labeling or blockade.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 170856-57-2
- 화학식: C20H27N3O
- 분자량:325.45
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[1]|
Human D4 Receptor 2.2 nM (Ki) |
In Vitro
U-99363E (1 μM; 16-18 h) antagonizes Quinpirole (HY-B1752)-induced mitogenesis in Chinese hamster ovary cells expressing the human dopamine D4 receptor[1].
U-99363E (1 μM; 1 h) binds with high affinity (Ki = 2.2 nM) and 126-fold selectivity to human dopamine D4 receptors (expressed in human embryonic kidney cell membranes) over rat D2i dopamine receptors, and exhibits at least 100-fold lower affinity for other tested dopaminergic, serotonergic, and adrenergic receptors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 170856-57-2
-
분자량 325.45
-
화학식 C20H27N3O
-
SMILES
CCOC1=CC=CN=C1N(C2CCN(CC2)CC3=CC=CC=C3)C
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
U-99363E Related Classifications
HY-169136 Related Classifications
Powered by Bioz