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Cat. No.: HY-182515

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U-19052

U-19052 is a selective competitive peptidoleukotriene D/E receptor antagonist. U-19052 acts as a reversible antagonist that not affecting responses to non-leukotriene agonists. U-19052 does not exhibit agonist activity or induce contraction in guinea pig tracheal or ileal strips. U-19052 is a leukotriene antagonist developed by modifying leukotriene chemical structure. U-19052 can be used for the research of allergic asthma and hypersensitivity diseases.

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CAS No.: 112682-32-3
화학식: C₃₁H₄₂O₆S
분자량:542.73

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

U-19052 Chemical Structure

CAS No.: 112682-32-3

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Biological Activity
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Biological Activity

제품 설명

All Leukotriene Receptor Isoforms :

In Vitro

U-19052 (10 μM; 30 min) acts as a selective, competitive antagonist of peptidoleukotriene receptors on guinea pig tracheal strips, with a pK_B of 6.43 against LTD₄, 5.80 against LTE₄, and 5.54 against LTC₄^[1].
U-19052 (10 μM; 10 min) inhibits LTE₄-induced contraction of guinea pig tracheal strips without exhibiting agonist activity^[1].
U-19052 (10 μM; 60 min) acts as a competitive antagonist of peptidoleukotriene receptors on guinea pig ileal segments, with a pK_B of 7.25 against LTD₄ and 7.17 against LTE₄^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 112682-32-3
분자량 542.73
화학식 C₃₁H₄₂O₆S
SMILES

CCCCCCCC(C=C1)=CC=C1C/C=C\[C@H]([C@@H](O)CCCC(O)=O)SCC2=C(C=C(C=C2)C(O)=O)OC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Bernstein PR, et al. Synthesis and pharmacological characterization of a series of leukotriene analogues with antagonist and agonist activities. J Med Chem. 1988 Mar;31(3):692-6. [Content Brief]

[2]. Terada H, et al. Structural requirements of leukotriene antagonists. Pharmacochem. Libr. 1995; 23:341-367.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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U-19052

All Leukotriene Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

U-19052 Related Classifications

HY-182515 Related Classifications