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Cat. No.: HY-180417

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U 88204

U 88204 is a potent HIV-1 reverse transcriptase (RT) inhibitor with an IC₅₀ of 0.25 μM. U 88204 blocks HIV-1 replication in infected cells. U 88204 can be used for the research on HIV-infection and of acquired immunodeficiency syndrome (AIDs).

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CAS No.: 136816-76-7
화학식: C₂₁H₂₅N₅O
분자량:363.47

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

U 88204 Chemical Structure

CAS No.: 136816-76-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MT2	CC₅₀	10 μM Compound: 4	Cytotoxic concentration against MT-2 cells Cytotoxic concentration against MT-2 cells	[PMID: 7684450]

In Vitro

U 88204 (compound 11) potently blocks HIV-1 replication in MT-2/IIIb, PBMC/D34, and H9/IIIb cells with ED₅₀ values of 0.3 μM, 0.001 μM, and 0.04 μM, respectively, while showing low cytotoxicity (CC₅₀ > 10 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 136816-76-7
분자량 363.47
화학식 C₂₁H₂₅N₅O
SMILES

O=C(C1=CC=2C=CC=CC2N1)N3CCN(C4=NC=CC=C4NC(C)C)CC3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xu H, et al. Progress of bis(heteroaryl)piperazines (BHAPs) as non-nucleoside reverse transcriptase inhibitors (NNRTIs) against human immunodeficiency virus type 1 (HIV-1). Mini Rev Med Chem. 2010;10(1):62-72. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(start) Concentration _(start)

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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U 88204

All HIV Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

U 88204 Related Classifications

HY-180417 Related Classifications