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Cat. No.: HY-181971

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XY25028

XY25028 is an orally active LRH-1 inhibitor with an IC₅₀ of 0.30 μM. XY25028 inhibits the proliferation of androgen receptor (AR)-positive prostate cancer cells and suppresses the expression of AR target genes KLK2 and KLK3. XY25028 can be used in the research of castration-resistant prostate cancer.

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화학식: C₃₂H₃₈N₂O₃
분자량:498.66

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

XY25028 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

XY25028 (96 h) inhibits the viability of 22Rv1, C4-2B and LNCaP human prostate cancer cell lines, with IC₅₀ values of 14.46 μM, 17.41 μM and 20.88 μM, respectively^[1].
XY25028 (10-40 μM; 48 h) inhibits the mRNA expression of KLK2 and KLK3 in 22Rv1 human prostate cancer cells in a dose-dependent manner^[1].
XY25028 (2.5-40 μM; 48 h) inhibits c-Myc protein expression in human prostate cancer cell line 22Rv1 after 48 h of treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

22Rv1 human prostate cancer cells
Concentration:

10 μM, 20 μM, 40 μM
Incubation Time:

48 h
Result:

Significantly reduced KLK3 mRNA levels.

Western Blot Analysis^[1]

Cell Line:

22Rv1 human prostate cancer cells
Concentration:

2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM
Incubation Time:

48 h
Result:

Significantly reduced c-Myc protein expression at 20 μM and 40 μM compared to vehicle control.
Showed no significant changes in c-Myc protein expression at 2.5 μM, 5 μM, or 10 μM compared to vehicle control.

In Vivo

XY25028 (50 mg/kg; p.o.; once daily; 16 days) elicits significant antitumor efficacy in a 22Rv1 CRPC xenograft model, with a 40.7% tumor growth inhibition rate and no detectable systemic toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c-Nude (male, 5 weeks old)^[1]
Dosage:

50 mg/kg
Administration:

p.o.; once daily; 16 consecutive days
Result:

Achieved a tumor growth inhibition (TGI) rate of 40.7%.
Showed no significant body weight changes (a marker of systemic toxicity) throughout the 16-day study period.

Chemical Information

분자량 498.66
화학식 C₃₂H₃₈N₂O₃
SMILES

NC1=CC=C(N(CC2=CC=CC=C2)C=C3C4=CC=C(OCCCCCCC(OC(C)(C)C)=O)C=C4)C3=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Ma K, et al. Discovery of novel indole derivatives as LRH-1 antagonists for the treatment of castration resistant prostate cancer. Eur J Med Chem. 2026;308:118681. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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