XYDC2050
XYDC2050 (Compound 29) is a selective vasopressin V2 receptor (V2R) antagonist with an IC50 of 27 nM and a Ki of 2.8 nM. XYDC2050 shows a Ki of 420.7 nM (SI = 162 fold) for V1R. XYDC2050 can inhibit Vasopressin (HY-B1811)-induced intracellular cyclic adenosine monophosphate (cAMP) accumulation with an IC50 of 12 nM. XYDC2050 can inhibit the growth of renal cysts, reduce the ratio of kidney weight to body weight and decrease the area of cysts and the cystic index. XYDC2050 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD).
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- 화학식: C33H25FN2O4
- 분자량:532.56
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All Vasopressin Receptor Isoforms
More
Biological Activity
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V2 Receptor 27 nM (IC50) |
V2 Receptor 2.8 nM (Ki) |
Chemical Information
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분자량 532.56
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화학식 C33H25FN2O4
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SMILES
FC1=CC=C(N(CC2=CC=C(O)C=C2)C(C3=CC(O)=C(NC(C4=CC=CC=C4C5=CC=CC=C5)=O)C=C3)=O)C=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
XYDC2050 Related Classifications
HY-180142 Related Classifications
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