Zecdarasib
Zecdarasib is a Kirsten rat sarcoma virus oncogene homolog (KRAS) inhibitor with antitumor activity. Zecdarasib can be used in tumor-related research.
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- CAS No.: 3080960-85-3
- 화학식: C35H32Cl2FN5O
- 분자량:628.57
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
제품 설명
IC50 & Target
[1]|
K-RAS |
Chemical Information
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CAS No. 3080960-85-3
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분자량 628.57
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화학식 C35H32Cl2FN5O
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SMILES
N#CCCC1=CC2=C(N=C(C3=C2N(C([C@@]4(N(C(C5CC5)=O)[C@@]6(C[C@@]6(C4)[H])[H])[H])=C3)[C@]7([C@]8(CN[C@@]7(C8)[H])[H])[H])C)C(F)=[C@]1[C@]9=C(Cl)C(Cl)=CC=C9
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)