Cat. No.: HY-102078

ZINC69391

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

ZINC69391, a specific Rac1 inhibitor, interferes with Rac1-GEF interaction by masking Trp56 residue on Rac1 surface. ZINC69391 interferes with the interaction of Rac1 with Dock180 and reduces Rac1-GTP levels. ZINC69391 induces apoptosis, and shows antiproliferative and antimetastatic effects.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.12%
CAS No.: 303094-67-9
화학식: C₁₄H₁₄F₃N₅
분자량:309.29

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

ZINC69391 Chemical Structure

CAS No.: 303094-67-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Ras Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	31 μM Compound: 13; ZINC69391	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37253305]
MDA-MB-231	IC₅₀	48 μM Compound: 13; ZINC69391	Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37253305]

In Vitro

ZINC69391 inhibits growth of U937, HL-60, KG1A and Jurkat cells with IC₅₀s ranging from 41 to 54 μM^[1].
ZINC69391 (50-100 μM; 24 hours) augments the enzymatic activity of caspase 3 in a concentration dependent manner^[1].
ZINC69391 (0-125 μM; 72h) reduces cell proliferation of human glioma cells^[2].
ZINC69391 (50-100 μM; 48 hours) triggers cell cycle arrest^[2].
ZINC69391 (50 μM; 24 hours) triggers apoptosis on human acute leukemic cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:

U-87 MG, LN229 cells
Concentration:

0-125μM
Incubation Time:

72 hours
Result:

Reduced cell proliferation in a concentration-dependent manner.

Cell Cycle Analysis^[2]

Cell Line:

LN229 cells
Concentration:

50, 100 μM
Incubation Time:

48 hours
Result:

Resulted in a significant increased percentage of cells in the sub-G0/G1 phase in a concentration dependent manner.

Apoptosis Analysis^[1]

Cell Line:

HL-60, U937 and KG1A cell lines
Concentration:

50 μM
Incubation Time:

24 hours
Result:

Led to a significant increase in apoptotic cells.

In Vivo

ZINC69391 (25 mg/kg; i.p; daily for 21 days) impairs metastatic lung colonization in a syngeneic animal model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Specific pathogen-free female BALB/c inbred mice (bearing F3II cells)^[3]
Dosage:

25 mg/kg body weight
Administration:

I.p; daily for 21 days
Result:

Significantly reduced by about 60% the formation of total metastatic lung colonies.

Chemical Information

CAS No. 303094-67-9
Appearance Solid
분자량 309.29
화학식 C₁₄H₁₄F₃N₅
Color White to off-white
SMILES

N=C(NC1=CC=CC=C1C(F)(F)F)NC2=NC(C)=CC(C)=N2
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Cell Rep

LncRNA DGCR5-encoded polypeptide RIP aggravates SONFH by repressing nuclear localization of β-catenin in BMSCs. [Abstract]

2023 Aug 12;42(8):112969. PMID: 37573506

용액&용해도

In Vitro:

DMSO : 25 mg/mL (80.83 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.2332 mL

16.1661 mL

32.3321 mL

5 mM

0.6466 mL

3.2332 mL

6.4664 mL

10 mM

0.3233 mL

1.6166 mL

3.2332 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cabrera M, et al. Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines. Oncotarget. 2017;8(58):98509‐98523. Published 2017 Oct 4. [Content Brief]

[2]. Cardama GA, et al. Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells. Onco Targets Ther. 2014;7:2021‐2033. Published 2014 Oct 30. [Content Brief]

[3]. Cardama GA, et al. Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines. Anticancer Agents Med Chem. 2014;14(6):840‐851. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.2332 mL	16.1661 mL	32.3321 mL	80.8303 mL
	5 mM	0.6466 mL	3.2332 mL	6.4664 mL	16.1661 mL
	10 mM	0.3233 mL	1.6166 mL	3.2332 mL	8.0830 mL
	15 mM	0.2155 mL	1.0777 mL	2.1555 mL	5.3887 mL
	20 mM	0.1617 mL	0.8083 mL	1.6166 mL	4.0415 mL
	25 mM	0.1293 mL	0.6466 mL	1.2933 mL	3.2332 mL
	30 mM	0.1078 mL	0.5389 mL	1.0777 mL	2.6943 mL
	40 mM	0.0808 mL	0.4042 mL	0.8083 mL	2.0208 mL
	50 mM	0.0647 mL	0.3233 mL	0.6466 mL	1.6166 mL
	60 mM	0.0539 mL	0.2694 mL	0.5389 mL	1.3472 mL
	80 mM	0.0404 mL	0.2021 mL	0.4042 mL	1.0104 mL

ZINC69391

1 Cited Publications

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ZINC69391

Apoptosis Compound Library

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

MAPK Compound Library

Anti-Cancer Compound Library

Oxygen Sensing Compound Library

Ferroptosis Compound Library

Glutamine Metabolism Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Angiogenesis-Related Compound Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Inhibitors Library

Highly Selective Activators Library

Cell Death Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) ZINC69391

All Ras Isoforms

Biological Activity

Chemical Information

Publications (1)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

ZINC69391

Apoptosis Compound Library

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

MAPK Compound Library

Anti-Cancer Compound Library

Oxygen Sensing Compound Library

Ferroptosis Compound Library

Glutamine Metabolism Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Angiogenesis-Related Compound Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Inhibitors Library

Highly Selective Activators Library

Cell Death Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) ZINC69391

All Ras Isoforms

Biological Activity

Chemical Information

Publications (1)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

ZINC69391 Related Classifications

HY-102078 Related Classifications