2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. ADC Payload Topoisomerase
  4. LD2-3

LD2-3 is a cytotoxic compound derived from Exatecan (HY-13631), designed to be conjugated with anti-FGFR2b or anti-CEA antibodies to form intact antibody-drug conjugate (ADC) molecules. LD2-3 exhibits a remarkable bystander killing effect: it not only effectively kills FGFR2b-positive tumor cells, but also eliminates surrounding FGFR2b-negative cells in co-culture and mixed tumor xenograft models, thereby inducing complete tumor regression. LD2-3 can be used for anti-tumor research in relevant fields such as gastric cancer and lung cancer.

For research use only. We do not sell to patients.

LD2-3

LD2-3 Chemical Structure

CAS No. : 3040077-52-6

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

LD2-3 Related Antibodies

Top Publications Citing Use of Products

View All ADC Payload Isoform Specific Products:

View All Isoforms
Auristatin Calicheamicins Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

View All Topoisomerase Isoform Specific Products:

View All Isoforms
Topoisomerase Topo I Topo II DNA gyrase

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

LD2-3 is a cytotoxic compound derived from Exatecan (HY-13631), designed to be conjugated with anti-FGFR2b or anti-CEA antibodies to form intact antibody-drug conjugate (ADC) molecules. LD2-3 exhibits a remarkable bystander killing effect: it not only effectively kills FGFR2b-positive tumor cells, but also eliminates surrounding FGFR2b-negative cells in co-culture and mixed tumor xenograft models, thereby inducing complete tumor regression. LD2-3 can be used for anti-tumor research in relevant fields such as gastric cancer and lung cancer[1][2].

IC50 & Target

Topoisomerase I

 

In Vitro

BGA3457 (anti-FGFR2b antibody BGAh9179 conjugated to LD2-3) (34.75 ng/mL) exhibits potent bystander killing activity against FGFR2b-negative HuTu-80-NanoLuc cells cocultured with FGFR2b-positive SNU-16 cells, with an IC50 of 34.75 ng/mL and a maximum killing potency of 90.74%[1].
BGA3457 and BGA9823 (anti-FGFR2b antibodies conjugated to LD2-3) exhibit comparable internalization activity in SNU16, SNU601-h2b, H1048-h2b, and HSC-39 cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LD2-3 Related Antibodies
In Vivo

LD2-3 (10 mg/kg; i.v.; single dose), as part of immunoconjugate FGFR2b-positive/negative gastric tumors in BALB/c nude mice[1].
LD2-3 (10 mg/kg; i.v.; single dose), as part of immunoconjugate BGA9823, induces complete regression of mixed FGFR2b-positive/negative gastric tumors in BALB/c nude mice[1].
LD2-3 (1-10 mg/kg; i.v.; single dose), as part of immunoconjugates BGA3457 and BGA9823, inhibits tumor growth in a FGFR2b-expressing gastric cancer xenograft model in BALB/c nude mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude (female, 6 to 8 weeks old)[1]
Dosage: 10 mg/kg (delivered as part of immunoconjugate BGA3457)
Administration: i.v.; single dose
Result: Induced complete tumor regression in both 2:1 and 5:1 HSC-39:SNU-5 co-inoculation models.
Molecular Weight

1244.28

Formula

C59H74FN11O18
CAS No.
SMILES

O=C(C=CC1=O)N1CC(NCCC(N[C@@H](CCC(NC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)CC(N)=O)=O)C(N[C@@H](C(C)C)C(N[C@@H](C)C(NCOCC(C)(C)C(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

LD2-3 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LD2-33040077-52-6ADC PayloadTopoisomeraseADC CytotoxinSNU16 cell linesH1048-h2b cell linesFGFR2bSNU601-h2b cell linesSNU-16 cellsgastric cancerHuTu-80-NanoLuc cellsBALB/c nude miceHSC-39 cell lineslung cancerInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
LD2-3
Cat. No.:
HY-178238
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.