2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. Mal-PEG4-VA-PBD

Mal-PEG4-VA-PBD is a agent-linker conjugate for ADC by using the antitumor antibiotic, Pyrrolobenzodiazepine (PBD), linked via Mal-PEG4-VA.

For research use only. We do not sell to patients.

Mal-PEG4-VA-PBD Chemical Structure

Mal-PEG4-VA-PBD Chemical Structure

CAS No. : 1342820-68-1

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1 mg USD 1090 In-stock
5 mg USD 3220 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Mal-PEG4-VA-PBD Related Antibodies

Top Publications Citing Use of Products

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

View All Isoforms
Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

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Description

Mal-PEG4-VA-PBD is a agent-linker conjugate for ADC by using the antitumor antibiotic, Pyrrolobenzodiazepine (PBD), linked via Mal-PEG4-VA.

IC50 & Target

Pyrrolobenzodiazepines

 

Molecular Weight

1294.40

Formula

C68H79N9O17
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

[H][C@]12N(C(C3=CC(OC)=C(OCCCOC4=C(C=C5C(N=C[C@@]6([H])N(C=C(C7=CC=C(OC)C=C7)C6)C5=O)=C4)OC)C=C3N=C2)=O)C=C(C8=CC=C(NC([C@H](C)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCNC(CCN9C(C=CC9=O)=O)=O)=O)=O)=O)C=C8)C1
Shipping

Shipping with dry ice.
Storage

-80°C, stored under nitrogen
Solvent & Solubility
In Vitro: 

DMSO : 190 mg/mL (146.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7726 mL 3.8628 mL 7.7256 mL
5 mM 0.1545 mL 0.7726 mL 1.5451 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (stored under nitrogen). When stored at -80°C, please use it within 6 months.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (stored under nitrogen). When stored at -80°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7726 mL 3.8628 mL 7.7256 mL 19.3140 mL
5 mM 0.1545 mL 0.7726 mL 1.5451 mL 3.8628 mL
10 mM 0.0773 mL 0.3863 mL 0.7726 mL 1.9314 mL
15 mM 0.0515 mL 0.2575 mL 0.5150 mL 1.2876 mL
20 mM 0.0386 mL 0.1931 mL 0.3863 mL 0.9657 mL
25 mM 0.0309 mL 0.1545 mL 0.3090 mL 0.7726 mL
30 mM 0.0258 mL 0.1288 mL 0.2575 mL 0.6438 mL
40 mM 0.0193 mL 0.0966 mL 0.1931 mL 0.4828 mL
50 mM 0.0155 mL 0.0773 mL 0.1545 mL 0.3863 mL
60 mM 0.0129 mL 0.0644 mL 0.1288 mL 0.3219 mL
80 mM 0.0097 mL 0.0483 mL 0.0966 mL 0.2414 mL
100 mM 0.0077 mL 0.0386 mL 0.0773 mL 0.1931 mL
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Mal-PEG4-VA-PBD Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mal-PEG4-VA-PBD1342820-68-1Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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