Menin-MLL inhibitor 20

Name: Menin-MLL inhibitor 20
Brand: MedChemExpress
SKU: HY-128798
Rating: 4.5 (0 reviews)

Cat. No.: HY-128798 Pureza: 98.81%: Ficha de datos
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Menin-MLL inhibitor 20 is an irreversible menin-MLL interaction inhibitor with antitumor activities (WO2020142557A1, Intermediate 6).

Para uso exclusivo en investigación. No vendemos a pacientes.

Menin-MLL inhibitor 20 Estructura química

No. CAS : 2448173-47-3

Tamaño	Stock	Cantidad

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Muestra gratis (0.1 - 0.2 mg)	Solicite ahora
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Based on 1 Customer Validation

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Epigenetic Reader Domain:

Ver todas las isoformas

Brd BRPF1 BRPF2 BRPF3 BRD2 BRD3 BRD4 BRDT CECR2 BD1 BD2 BRD7 BRD9 BET BAZ

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

Menin-MLL inhibitor 20 is an irreversible menin-MLL interaction inhibitor with antitumor activities (WO2020142557A1, Intermediate 6)^[1].

In Vitro

The Histone-lysine N-methyltransferase 2 (KMT2) family of proteins, which currently consists of at least 5 members, methylate ly sine 4 on the histone H3 tails at important regulatory regions in the genome and thereby impart crucial functions through the modulation of chromatin structures and DNA accessibility. These enzymes are known to play an important role in the regulation of gene expression during early development and hematopoiesis. The human KMT2 family was initially named the mixed-lineage leukaemia (MLL) family, owing to the role of the first-found member in this disease^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

612.72

Fòrmula

C₃₃H₄₀N₈O₄

No. CAS

2448173-47-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(OC(C)(C)C)N[C@H]1CN(CC2=CC(C(NC3=CC=C(C4=CC5=C(N6CCOCC6)N=CN=C5N4)C=C3)=O)=NC=C2)CCC1

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 33.33 mg/mL (54.40 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6321 mL	8.1603 mL	16.3207 mL
5 mM	0.3264 mL	1.6321 mL	3.2641 mL
10 mM	0.1632 mL	0.8160 mL	1.6321 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 98.81%

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Ficha de datos (269 KB) SDS (251 KB)

COA (246 KB) HNMR (315 KB) LCMS (94 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Thomas Butler, et al. Irreversible inhibitors of menin-mll interaction. WO2020142557A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6321 mL	8.1603 mL	16.3207 mL	40.8017 mL
	5 mM	0.3264 mL	1.6321 mL	3.2641 mL	8.1603 mL
	10 mM	0.1632 mL	0.8160 mL	1.6321 mL	4.0802 mL
	15 mM	0.1088 mL	0.5440 mL	1.0880 mL	2.7201 mL
	20 mM	0.0816 mL	0.4080 mL	0.8160 mL	2.0401 mL
	25 mM	0.0653 mL	0.3264 mL	0.6528 mL	1.6321 mL
	30 mM	0.0544 mL	0.2720 mL	0.5440 mL	1.3601 mL
	40 mM	0.0408 mL	0.2040 mL	0.4080 mL	1.0200 mL
	50 mM	0.0326 mL	0.1632 mL	0.3264 mL	0.8160 mL