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  3. Menin-MLL inhibitor 20

Menin-MLL inhibitor 20 

Cat. No.: HY-128798
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Menin-MLL inhibitor 20 is an irreversible menin-MLL interaction inhibitor with antitumor activities (WO2020142557A1, compound 6).

For research use only. We do not sell to patients.

Menin-MLL inhibitor 20 Chemical Structure

Menin-MLL inhibitor 20 Chemical Structure

CAS No. : 2448173-47-3

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Estimated Time of Arrival: December 31
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100 mg USD 1450 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Menin-MLL inhibitor 20 is an irreversible menin-MLL interaction inhibitor with antitumor activities (WO2020142557A1, compound 6)[1].

In Vitro

The Histone-lysine N-methyltransferase 2 (KMT2) family of proteins, which currently consists of at least 5 members, methylate ly sine 4 on the histone H3 tails at important regulatory regions in the genome and thereby impart crucial functions through the modulation of chromatin structures and DNA accessibility. These enzymes are known to play an important role in the regulation of gene expression during early development and hematopoiesis. The human KMT2 family was initially named the mixed-lineage leukaemia (MLL) family, owing to the role of the first-found member in this disease[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

612.72

Formula

C₃₃H₄₀N₈O₄

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (54.40 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6321 mL 8.1603 mL 16.3207 mL
5 mM 0.3264 mL 1.6321 mL 3.2641 mL
10 mM 0.1632 mL 0.8160 mL 1.6321 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Menin-MLL inhibitor 20
Cat. No.:
HY-128798
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