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Art. -Nr.: HY-15613A

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(-)-Maritoclax

Name: (-)-Maritoclax
Brand: MedChemExpress
SKU: HY-15613A
Availability: PreOrder

(Synonyms: (-)-Marinopyrrole A)

(-)-Maritoclax ((-)-Marinopyrrole A) is an actin-targeting cytotoxic and antibacterial agent. (-)-Maritoclax exhibits cytotoxicity against cancer cells. (-)-Maritoclax can be used in the research of methicillin-resistant Staphylococcus aureus infections and colon cancer.

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CAS. Nr.: 1010732-14-5
Formel: C₂₂H₁₂Cl₄N₂O₄
Molecular Weight:510.15

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

(-)-Maritoclax Chemical Structure

CAS. Nr.: 1010732-14-5

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

Alle Actin Isoform-spezifische Produkte anzeigen :

β-Actin

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	8.8 μM Compound: 40	Anticancer activity against human HCT-116 cells assessed as cell growth inhibition Anticancer activity against human HCT-116 cells assessed as cell growth inhibition	[PMID: 36058089]
HCT-116	IC50	4.5 μg/mL	Cytotoxicity against human HCT-116 colon cancer cells, quantified as inhibition of cell viability. Cytotoxicity against human HCT-116 colon cancer cells, quantified as inhibition of cell viability.	20405892
HeLa	IC₅₀	20 μM Compound: Marinopyrrole A	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs	[PMID: 29407973]
RS4-11	IC₅₀	2 μM Compound: Marinopyrrole A	Cytotoxicity against human RS4:11 cells assessed as reduction in cell viability after 72 hrs Cytotoxicity against human RS4:11 cells assessed as reduction in cell viability after 72 hrs	[PMID: 29407973]

In Vitro

(-)-Maritoclax potently inhibits methicillin-resistant Staphylococcus aureus (MRSA) with a MIC₉₀ of 0.31 μg/mL^[1].
(-)-Maritoclax exhibits cytotoxicity against HCT-116 human colon cancer cells with an IC₅₀ of 4.5 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1010732-14-5
Molecular Weight 510.15
Formel C₂₂H₁₂Cl₄N₂O₄
SMILES

O=C(C=1C=CC=CC1O)C2=CC(Cl)=C(Cl)N2C=3C(Cl)=C(Cl)NC3C(=O)C=4C=CC=CC4O
Synonyms

(-)-Marinopyrrole A
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
- Microorganisms
Streptomyces sp. CNQ-418
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Hughes CC, et al. Structures, reactivities, and antibiotic properties of the marinopyrroles A-F. The Journal of organic chemistry. 2010 May 21;75(10):3240-50.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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