MNI-135
MNI-135 is a selective group II metabotropic glutamate receptor (mGluR) inhibitor. MNI-135 shows no inhibitory activity against group I or group III mGluRs.
For research use only. We do not sell to patients.
- CAS No.: 335257-47-1
- Formula: C16H10IN3O
- Molecular Weight:387.18
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
mGluR2 |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293-A | IC50 |
19.6 nM
|
Inhibition of glutamate-induced calcium mobilization in HEK293A cells expressing rat mGluR2 measured via calcium indicator dye and FLEXstation II after 5 min preincubation with MNI-135 followed by glutamate stimulation.
Inhibition of glutamate-induced calcium mobilization in HEK293A cells expressing rat mGluR2 measured via calcium indicator dye and FLEXstation II after 5 min preincubation with MNI-135 followed by glutamate stimulation.
|
17416742 |
| HEK293-A | IC50 |
21.4 nM
|
Inhibition of glutamate-induced calcium mobilization in HEK293A cells expressing wild-type human mGluR2 measured via calcium indicator dye and FLEXstation II after 5 min preincubation with MNI-135 followed by glutamate stimulation.
Inhibition of glutamate-induced calcium mobilization in HEK293A cells expressing wild-type human mGluR2 measured via calcium indicator dye and FLEXstation II after 5 min preincubation with MNI-135 followed by glutamate stimulation.
|
17416742 |
| HEK293-A | IC50 |
24.4 nM
|
Inhibition of glutamate-induced calcium mobilization in HEK293A cells expressing N735D mutant human mGluR2 measured via calcium indicator dye and FLEXstation II after 5 min preincubation with MNI-135 followed by glutamate stimulation.
Inhibition of glutamate-induced calcium mobilization in HEK293A cells expressing N735D mutant human mGluR2 measured via calcium indicator dye and FLEXstation II after 5 min preincubation with MNI-135 followed by glutamate stimulation.
|
17416742 |
In Vitro
MNI-135 potently inhibits glutamate-induced calcium mobilization in HEK293A cells expressing rmGluR2, with an IC50 of 19.6 nM[1].
MNI-135 potently inhibits glutamate-induced calcium mobilization in CHO cells expressing hmGluR2, with an IC50 value of 10.51 nM[1].
MNI-135 inhibits [35S]GTPγS binding to glutamate-stimulated CHO cell membranes expressing hmGluR2, with an IC50 of 118.2 nM[1].
MNI-135 (60 min) inhibits glutamate-induced [35S]GTPγS binding to membranes of CHO cells expressing rmGluR3, with an IC50 of 30.2 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 335257-47-1
-
Molecular Weight 387.18
-
Formula C16H10IN3O
-
SMILES
N#CC1=CC=CC(=C1)C2=NC3=CC=C(I)C=C3NC(=O)C2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MNI-135 Related Classifications
HY-119474 Related Classifications
Powered by Bioz