Bethanechol
Based on 4 publication(s) in Google Scholar
Bethanechol (Carbamyl-β-methylcholine), a parasympathomimetic agent, is a mAChR agonist that exerts its effects via directly stimulating the mAChR (M1, M2, M3, M4, and M5) of the parasympathetic nervous system.
At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Bethanechol chloride) usually boasts enhanced water solubility and stability.
For research use only. We do not sell to patients.
- CAS No.: 674-38-4
- Formula: C7H17N2O2
- Molecular Weight:161.22
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Bethanechol
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Biological Activity
Description
IC50 & Target
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mAChR1 |
mAChR3 |
mAChR4 |
mAChR5 |
In Vitro
Bethanechol (0.3-300 μM) significantly reduces ileal pacemaker potentials[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female rats of the Blue Spruce Farms (Sprague-Dawley) (280-330 g) [4]
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Dosage:2 mg/kg, 4 mg/kg, 8 mg/kg, 12 mg/kg
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Administration:Intraperitoneal injection
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Result:Increased water intake during the first hr in a dose-dependent fashion up to the highest dose administered (12 mg/kg).
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 674-38-4
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Molecular Weight 161.22
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Formula C7H17N2O2
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SMILES
CC(OC(N)=O)C[N+](C)(C)C
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Synonyms
Carbamyl-β-methylcholine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (4)
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Journal Impact Factor
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Most Recent
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Cell Stem Cell
Vagal pathway activation links chronic stress to decline in intestinal stem cell function. [Abstract]2025 Mar 20:S1934-5909(25)00084-0. PMID: 40120585 -
Acta Pharmacol Sin
Activation of peripheral muscarinic receptors rescues depressive-like behaviors via gut-brain-axis, involving parasympathetic excitation. [Abstract]2026 May 29. PMID: 42215618 -
Purity & Documentation
References
[1]. Inderbir S. Padda, et al. Bethanechol. Treasure Island (FL): StatPearls Publishing; 2020 Jan-.
[2]. Julia Yuen Hang Liu, et al. Acetylcholine exerts inhibitory and excitatory actions on mouse ileal pacemaker activity: role of muscarinic versus nicotinic receptors. Am J Physiol Gastrointest Liver Physiol. 2020 Jul 1;319(1):G97-G107. [Content Brief]
[3]. M J Fregly, et al. Bethanechol-induced water intake in rats: possible mechanisms of induction. Pharmacol Biochem Behav. 1982 Oct;17(4):727-32. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Bethanechol Related Classifications
HY-B0406 Related Classifications
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