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FCCP

(Synonyms: Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone)
117 Cited Publications
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Based on 117 publication(s) in Google Scholar

FCCP is an uncoupler of oxidative phosphorylation (OXPHOS) in mitochondria. FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation.

For research use only. We do not sell to patients.

  • Purity: 99.69%
  • CAS No.: 370-86-5
  • Formula: C10H5F3N4O
  • Molecular Weight:254.17
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • FCCP Chemical Structure
    FCCP Chemical Structure
  • Experimental Validation Results for FCCP
  • Experimental Validation Results for FCCP
  • Experimental Validation Results for FCCP
  • Experimental Validation Results for FCCP
  • Experimental Validation Results for FCCP
  • Experimental Validation Results for FCCP
CAS No.: 370-86-5
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Cell Proliferation/Viability Assay
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  • FCCP Chemical Structure
    FCCP Chemical Structure
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    FCCP purchased from MedChemExpress. Usage Cited in: Nature. 2025 Mar;639(8055):765-775. [Abstract]

    Customer Validation
     OCR of neuroendocrine (n=4) and non-neuroendocrine (n=2) SCLC cell lines after FCCP (1.5 μM, 40 min) treatment (n=6 technical replicates for each cell line).

  • 1/16

    FCCP purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jul 30;16(1):6996. [Abstract]

    Customer Validation
     The mitophagy index of shRNA- or non-transduced 528NS and HOG-GSCs treated for 3 days with or without MitoTEMPOL (100 nM) on day 4 after shRNA transduction. FCCP (30 μM) and RA were used as positive controls.

  • 1/16

    FCCP purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 Aug 28;12(1):49. [Abstract]

    Customer Validation
     Immunofluorescence staining to show the CTSK expression level in osteoclasts that were treated with oligomycin A (10 nmol/L), rotenone (100 nmol/L), FCCP (1 μmol/L), 2DG (1 μmol/L) or 3BrPA (1 μmol/L) for 6 h (scale bar, 100 µm).

  • 1/16

    FCCP purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 Aug 28;12(1):49. [Abstract]

    Customer Validation
     Immunoblots of the pre-proenzyme and active CTSK levels in osteoclasts treated with 2DG (1 μmol/L), FCCP (1 μmol/L), rotenone (100 nmol/L) or 3-BrPA (1 μmol/L) for 10 h. The MMP-9 and CTSB expression levels were also detected. DMSO-treated osteoclasts were used as controls.

  • 1/16

    FCCP purchased from MedChemExpress. Usage Cited in: Cancer Res. 2023 Dec 15;83(24):4063-4079. [Abstract]

    Customer Validation
     Viability of Glut5-overexpressing and control cells cultured for 24 hours under different conditions in the presence of Rotenone or FCCP (10 μmol/L).

  • 1/16

    FCCP purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 May 13;13(1):2673. [Abstract]

    Customer Validation
     Flow cytometry analysis of WT and Myo19 KO cells stained with 100 nM TMRM for 20 min. 5 μM FCCP treatment for 10 min was used as positive.

  • FCCP