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Cat. No.: HY-112840

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ST3932

ST3932 is a metabolite of ST1535, acts as an antagonist of adenosine A_2A receptor, with K_is of 8 nM and 33 nM for A_2A and A₁ receptors, respectively.

For research use only. We do not sell to patients.

CAS No.: 1246018-21-2
Formula: C₁₂H₁₆N₈O
Molecular Weight:288.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

ST3932 Chemical Structure

CAS No.: 1246018-21-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

ST3932 is a metabolite of ST1535, acts as an antagonist of adenosine A_2A receptor, with K_is of 8 nM and 33 nM for A_2A and A₁ receptors, respectively.

IC₅₀ & Target

Ki: 8 nM (A_2A receptor), 33 nM (A₁ receptor)^[1]

All Adenosine Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	450 nM Compound: 16a, (R,S)-16a	Antagonist activity at human adenosine A2A receptor expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP accumulation incubated for 10 mins prior to NECA addition Antagonist activity at human adenosine A2A receptor expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP accumulation incubated for 10 mins prior to NECA addition	[PMID: 23789814]

In Vitro

ST3932 is a metabolite of ST1535, acts as an antagonist of adenosine A_2A receptor, with K_is of 8 nM and 33 nM for A_2A and A₁ receptors, respectively. ST3932 inhibits agonist-induced cAMP accumulation with an IC₅₀ value of 450 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ST3932 (10, 20, 40 mg/kg, p.o.) antagonizes haloperidol-induced catalepsy, and increases motor activity in mice. ST3932 (20, 40 mg/kg, i.p.) significantly increases the number of contralateral turns induced by l-DOPA in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1246018-21-2
Molecular Weight 288.31
Formula C₁₂H₁₆N₈O
SMILES

OC(C)CCC1=NC(N(C)C(N2N=CC=N2)=N3)=C3C(N)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. ST3932, et al. Animal models of Parkinson׳s disease: Effects of two adenosine A2A receptor antagonists ST4206 and ST3932, metabolites of 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine (ST1535). Eur J Pharmacol. 2015 Aug 15;761:353-61. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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