Gentamicin C2
Gentamicin C2 is an aminoglycoside antibiotic with broad-spectrum bactericidal activity, selectively binding to the bacterial 16S rRNA A-site. Gentamicin C2 interferes with protein synthesis initiation and translation fidelity to exert bactericidal effects. Gentamicin C2 can be used for the research of bacterial infections.
For research use only. We do not sell to patients.
- CAS No.: 25876-11-3
- Formula: C20H41N5O7
- Molecular Weight:463.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
| Species | Dose | Route | AUC0-∞ | CL | Vss | MRT | T1/2 |
|---|---|---|---|---|---|---|---|
| Dog[2] | 2 mg/kg | i.v. | 41820 μg·h/mL | 1.82 mL/min/kg | 0.15 L/kg | 84 min | 66 min |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Beagle (4 males, 2 females, 16-20 kg)[2]
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Dosage:1.984 mg/kg
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Administration:i.v.; single bolus
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Result:Achieved a mean area under the plasma concentration-time curve (AUC) of 697 μg·mL-1·min.
Reached a total body clearance (CL) of 1.82 mL·min-1·kg-1.
Attained a volume of distribution at steady state (Vss) of 0.15 liter/kg.
Had a mean residence time (MRT) of 84 min.
Exhibited a terminal half-life (t1/2) of 66 min.
Showed an elimination rate constant (β) of 0.011 min-1.
Reached a volume of distribution in the elimination phase (Vβ) of 0.17 liter/kg.
Demonstrated statistically significant differences in CL, Vss, and Vβ compared to Gentamicin C1 (P = 0.0156).
Showed no statistically significant differences in any parameters compared to Gentamicin C1a.
Had no differences in MRT and t1/2 compared to Gentamicin C1 and Gentamicin C1a.
Chemical Information
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CAS No. 25876-11-3
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Molecular Weight 463.57
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Formula C20H41N5O7
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SMILES
O[C@@H]([C@@H]1O[C@H]([C@@H](CC2)N)O[C@]2([H])[C@H](N)C)[C@H]([C@@H](C[C@@H]1N)N)O[C@@H](OC[C@@]3(O)C)[C@@H]([C@H]3NC)O
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Structure Classification
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Initial Source
Micromonospora spp
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Gu Y, et al. Biosynthesis of Epimers C2 and C2a in the Gentamicin C Complex. Chembiochem. 2015;16(13):1933-1942. [Content Brief]
[2]. Isoherranen N, et al. Pharmacokinetics of gentamicin C(1), C(1a), and C(2) in beagles after a single intravenous dose. Antimicrob Agents Chemother. 2000 Jun;44(6):1443-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Gentamicin C2 Related Classifications
HY-N11857 Related Classifications
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