N-Acetyl-5-hydroxytryptamine-d3
Based on 1 Customer Validation
N-Acetyl-5-hydroxytryptamine-d3 is the deuterium labeled N-Acetyl-5-hydroxytryptamine. N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor.
For research use only. We do not sell to patients.
- Purity: 98.02%
- CAS No.: 2001098-07-1
- Formula: C12H11D3N2O2
- Molecular Weight:221.27
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2001098-07-1
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Unlabeled Cas 1210-83-9
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Appearance Solid
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Molecular Weight 221.27
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Formula C12H11D3N2O2
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Color White to off-white
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SMILES
[2H]C([2H])([2H])C(NCCC(C1=C2)=CNC1=CC=C2O)=O
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Synonyms
N-Acetylserotonin-d3; Normelatonin-d3; O-Demethylmelatonin-d3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (451.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Jang SW, et al. N-acetylserotonin activates TrkB receptor in a circadian rhythm. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3876-81. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.5194 mL | 22.5968 mL | 45.1937 mL | 112.9841 mL |
| 5 mM | 0.9039 mL | 4.5194 mL | 9.0387 mL | 22.5968 mL | |
| 10 mM | 0.4519 mL | 2.2597 mL | 4.5194 mL | 11.2984 mL | |
| 15 mM | 0.3013 mL | 1.5065 mL | 3.0129 mL | 7.5323 mL | |
| 20 mM | 0.2260 mL | 1.1298 mL | 2.2597 mL | 5.6492 mL | |
| 25 mM | 0.1808 mL | 0.9039 mL | 1.8077 mL | 4.5194 mL | |
| 30 mM | 0.1506 mL | 0.7532 mL | 1.5065 mL | 3.7661 mL | |
| 40 mM | 0.1130 mL | 0.5649 mL | 1.1298 mL | 2.8246 mL | |
| 50 mM | 0.0904 mL | 0.4519 mL | 0.9039 mL | 2.2597 mL | |
| 60 mM | 0.0753 mL | 0.3766 mL | 0.7532 mL | 1.8831 mL | |
| 80 mM | 0.0565 mL | 0.2825 mL | 0.5649 mL | 1.4123 mL | |
| 100 mM | 0.0452 mL | 0.2260 mL | 0.4519 mL | 1.1298 mL |
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