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Protoporphyrin IX

(Synonyms: PPIX)
22 Cited Publications
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Based on 22 publication(s) in Google Scholar

Protoporphyrin IX is a final intermediate in the heme biosynthetic pathway, which acts as a radiation sensitizer enhancing ROS generation even in a hypoxic state and inducing DNA damage. Protoporphyrin IX also acts as a photo sensitizer undergoing photobleaching that occurs through direct degradation by light irradiation. Protoporphyrin IX is formed and accumulated following 5-aminolevulinic acid (5-ALA) (HY-W000450) administration in the tumor cells of rats. Protoporphyrin IX causes selective improvement of basal cell carcinoma when activated red fluorescence of a peak wavelength at 405 nm. Protoporphyrin IX is promising for research of sonodynamic and photodynamic agents for a wide range of cancers, such as bladder cancer and nodular basal cell carcinoma.

For research use only. We do not sell to patients.

  • Purity: 98.0%
  • CAS No.: 553-12-8
  • Formula: C34H34N4O4
  • Molecular Weight:562.66
  • Storage:

    4°C, protect from light, stored under nitrogen

    * In solvent : -80°C, 1 year; -20°C, 6 months (protect from light, stored under nitrogen)

  • Protoporphyrin IX Chemical Structure
    Protoporphyrin IX Chemical Structure
  • Experimental Validation Results for Protoporphyrin IX
  • Experimental Validation Results for Protoporphyrin IX
  • Experimental Validation Results for Protoporphyrin IX
  • Experimental Validation Results for Protoporphyrin IX
  • Experimental Validation Results for Protoporphyrin IX
  • Experimental Validation Results for Protoporphyrin IX
  • Experimental Validation Results for Protoporphyrin IX
CAS No.: 553-12-8
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  • Protoporphyrin IX Chemical Structure
    Protoporphyrin IX Chemical Structure
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    Protoporphyrin IX purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 Jun 21;22(1):358. [Abstract]

    Customer Validation
     UV-vis spectra of TPZ, Protoporphyrin IX, PP@PLGA, TP@PLGA and PTP@PLGA.

  • 1/16

    Protoporphyrin IX purchased from MedChemExpress. Usage Cited in: Genome Biol. 2022 Dec 15;23(1):259. [Abstract]

    Customer Validation
     Protoporphyrin IX (PpIX; 0, 5, 15, 25 µM; 2 h) rapidly results in increased nuclear G4 levels in HeLa cells. Immunostaining of G4 using BG4-EGFP (green). The nuclei are stained with DAPI (blue).

  • 1/16

    Protoporphyrin IX purchased from MedChemExpress. Usage Cited in: Sci Bull. 2021 May 15;66(9):925-936. [Abstract]

    Customer Validation
     Protoporphyrin IX (for 49 h) and Verteporfin, displayed a complete suppression of viral CPE at 1.25 µmol/L and 0.31 µmol/L, respectively. Viral N protein expression in infected Vero E6 cells was assessed by immunofluorescence.

  • 1/16

    Protoporphyrin IX purchased from MedChemExpress. Usage Cited in: Sci Bull. 2021 May 15;66(9):925-936. [Abstract]

    Customer Validation
     Antiviral effect and cell cytotoxicity of Protoporphyrin IX (0-320 μmol/L, 49 h) and verteporfin. The viral RNA production in the supernatant of infected Vero E6 cells was quantified with qRT-PCR.

  • 1/16

    Protoporphyrin IX purchased from MedChemExpress. Usage Cited in: Sci Bull. 2021 May 15;66(9):925-936. [Abstract]

    Customer Validation
     Schematic presentation of treatment timing of Protoporphyrin IX and verteporfin. Briefly, Vero E6 cells were treated with Protoporphyrin IX, verteporfin or the solvent DMSO before viral infection, during viral entry and after viral entry. A total of 8 treatment groups (I–VIII) for each compound were set up.

  • 1/16

    Protoporphyrin IX purchased from MedChemExpress. Usage Cited in: Sci Bull. 2021 May 15;66(9):925-936. [Abstract]

    Customer Validation
     Blocking effect on ACE2 and SARS-CoV-2 S-mediated cell–cell fusion by Protoporphyrin IX (2.5 μmol/L, pre-treatment for one hour) and verteporfin. The inhibitory value of protoporphyrin IX or verteporfin-treated group was presented relative to that of the DMSO-treated group which was set as 100%, respectively.

  • 1/16

    Protoporphyrin IX purchased from MedChemExpress. Usage Cited in: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Jul;27(7):568-73. [Abstract]

    Customer Validation
     To determine whether the inhibition of caveolin-1 tyrosine residues 14 ( Cav-1-Y14 ) phosphorylation with protein tyrosine kinase inhibitors ( PP2 ) will upregulate heme oxygenase-1 ( HO-1 ) activity to protect against ventilation induced lung injury in vivo of an animal model. The group D1 or D2 receive high tidal volume ventilation for 1 hour or 2 hour respectively, but they are given PP2 1 hour before high tidal volume ventilation. The groups E1 and E2 also receive high tidal volume ventilat

  • Protoporphyrin IX