Bafilomycin B1
Based on 1 publication(s) in Google Scholar
Bafilomycin B1 is a macrolide antibiotic that can be isolated from mycelium of Streptomyces gresuis. Bafilomycin B1 is neuroprotective against Chloroquine (HY-17589A)-induced death. Bafilomycin B1 is a structural analog of Bafilomycin A1 and has the ability to inhibit V-ATPase. Bafilomycin B1 inhibits significantly the oxidized low density lipoprotein (LDL)-induced accumulation of lipid droplets.
For research use only. We do not sell to patients.
- Purity: 98.10%
- CAS No.: 88899-56-3
- Formula: C44H65NO13
- Molecular Weight:815.99
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Bafilomycin B1
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Biological Activity
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Macrolide |
Bafilomycin B1 (Compound BafB1) (1 nM, 24 h) significantly inhibits the chloroquine-induced death of cerebellar granule neurons[1].
Bafilomycin B1 (Compound BafB1) (0.1-10 nM, 48 h) does not induce SH-SY5Y cell death or apoptosis at concentration ≤ 1 nM and significantly attenuates chloroquine-induced cell death with the addition of 50 μM chloroquine[2].
Bafilomycin B1 (5-10 nM) significantly inhibits the [14C]oleate incorporation into cholesteryl esters in J774 cells incubated with [14C]oleate in the presence of oxidized LDL for 3 h[3].
Bafilomycin B1 (10-40 nM) significantly inhibits the surface binding, intracellular accumulation and degradation of oxidized 125I-LDL in J774 cells incubated with oxidized 125I-LDL at 37 °C[3].
Bafilomycin B1 (50 nM, 20 min) inhibits 74% of the degradation of the internalized oxidized 125I-LDL in J774 cells, suggesting Bafilomycin B1 inhibits the endosomal and lysosomal functions[3].
Bafilomycin B1 (50 nM, 60 min) causes a reduction of the cell surface receptors for oxidized LDL when incubated with oxidized 125I-LDL at 37 °C[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 88899-56-3
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Appearance Solid
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Molecular Weight 815.99
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Formula C44H65NO13
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Color Off-white to yellow
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SMILES
O=C(O[C@@H]1C[C@@]([C@@H](C)[C@H](O)[C@@H]([C@H]([C@@H](OC)/C=C/C=C(C)/C[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C=C2\OC)OC2=O)C)(O)O[C@H](C(C)C)[C@H]1C)/C=C/C(NC3=C(O)CCC3=O)=O
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Structure Classification
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Initial Source
Streptomyces halstedii K122
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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iScience
Erythrabyssin ll is identified as a late-stage autophagy inhibitor reversing chemoresistance and promoting apoptosis in ovarian cancer. [Abstract]2025 Nov 6;28(7):112801. PMID: 40881620
Solvent & Solubility
DMSO : 100 mg/mL (122.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
[1]. Shacka, J. J., et al., (2006). Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection. Autophagy, 2(3), 228–230. [Content Brief]
[2]. Pivtoraiko, V. N., et al., (2010). Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction. Journal of neurochemistry, 114(4), 1193–1204. [Content Brief]
[3]. Naganuma, S., et al., (1992). Inhibition of the accumulation of lipid droplets in macrophage J774 by bafilomycin B1 and destruxin E. Biochimica et biophysica acta, 1126(1), 41–48. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2255 mL | 6.1275 mL | 12.2551 mL | 30.6376 mL |
| 5 mM | 0.2451 mL | 1.2255 mL | 2.4510 mL | 6.1275 mL | |
| 10 mM | 0.1226 mL | 0.6128 mL | 1.2255 mL | 3.0638 mL | |
| 15 mM | 0.0817 mL | 0.4085 mL | 0.8170 mL | 2.0425 mL | |
| 20 mM | 0.0613 mL | 0.3064 mL | 0.6128 mL | 1.5319 mL | |
| 25 mM | 0.0490 mL | 0.2451 mL | 0.4902 mL | 1.2255 mL | |
| 30 mM | 0.0409 mL | 0.2043 mL | 0.4085 mL | 1.0213 mL | |
| 40 mM | 0.0306 mL | 0.1532 mL | 0.3064 mL | 0.7659 mL | |
| 50 mM | 0.0245 mL | 0.1226 mL | 0.2451 mL | 0.6128 mL | |
| 60 mM | 0.0204 mL | 0.1021 mL | 0.2043 mL | 0.5106 mL | |
| 80 mM | 0.0153 mL | 0.0766 mL | 0.1532 mL | 0.3830 mL | |
| 100 mM | 0.0123 mL | 0.0613 mL | 0.1226 mL | 0.3064 mL |
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