ARAF - A-Raf proto-oncogene, serine/threonine kinase Gene

Also Known as PKS2; A-RAF; ARAF1; RAFA1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 369

About ARAF

Cytogenetic location: Xp11.3 Genomic coordinates (GRCh38): X:47,561,205-47,571,908 (from NCBI)

This gene has 5 transcripts (splice variants), 191 orthologues, 23 paralogues and is associated with 79 phenotypes. Ubiquitous expression in bone marrow (RPKM 16.5), spleen (RPKM 14.0) and 25 other tissues.

Summary

This proto-oncogene belongs to the Raf subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]

ARAF Products (3)

mRNA	Protein	Name
NM_001256196.2	NP_001243125.1	serine/threonine-protein kinase A-Raf isoform 2
NM_001256197.2	NP_001243126.1	serine/threonine-protein kinase A-Raf isoform 3
NM_001654.5	NP_001645.1	serine/threonine-protein kinase A-Raf isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11909642	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	19667065	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	19667065	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	19667065	GOA
involved in regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	22609986	GOA
involved in regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	22609986	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARAF Protein Structure

RBD

C1_1

Pkinase_Tyr

0
100
200
300
400
500
606 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase A-Raf	A-Raf proto-oncogene serine/threonine-protein kinase

ARAF Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ARAF	P10398	MAP2K2	Homo sapiens	P36507	Pull Down	32707033
Intra	ARAF	P10398	MAP2K2	Homo sapiens	P36507	Y2H	11909642
Intra	ARAF	P10398	MAP2K2	Homo sapiens	P36507	Y2H	21988832
Intra	ARAF	P10398	MAP2K2	Homo sapiens	P36507	Anti Tag CoIP	25852190
Intra	ARAF	P10398	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	31980649
Intra	ARAF	P10398	YWHAZ	Homo sapiens	P63104	Pull Down	32707033
Intra	ARAF	P10398	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	35271311
Intra	ARAF	P10398	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	25852190
Intra	ARAF	P10398	YWHAZ	Homo sapiens	P63104	CoIP	20052757
Intra	ARAF	P10398	HRAS	Homo sapiens	P01112	Y2H	12620389
Intra	ARAF	P10398	COPS3	Homo sapiens	Q9UNS2	Y2H	12620389
Intra	ARAF	P10398	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	22939624
Intra	ARAF	P10398	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	31980649
Intra	ARAF	P10398	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	25036637
Intra	ARAF	P10398	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	ARAF	P10398	TIMM50	Homo sapiens	Q3ZCQ8	Anti Tag CoIP	25852190
Intra	ARAF	P10398	TIMM50	Homo sapiens	Q3ZCQ8	Y2H	12620389
Intra	ARAF	P10398	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	25852190
Intra	ARAF	P10398	YWHAE	Homo sapiens	P62258	Pull Down	32707033
Intra	ARAF	P10398	SFN	Homo sapiens	P31947	Anti Tag CoIP	31980649
Intra	ARAF	P10398	SFN	Homo sapiens	P31947	Anti Tag CoIP	25852190
Intra	ARAF	P10398	RRAS2	Homo sapiens	P62070	Y2H	12620389
Intra	ARAF	P10398	RABGGTB	Homo sapiens	P53611	Y2H	12620389
Intra	ARAF	P10398	NELFCD	Homo sapiens	Q8IXH7	Y2H	12620389
Intra	ARAF	P10398	NELFCD	Homo sapiens	Q8IXH7	Y2H	21988832
Intra	ARAF	P10398	PRPF6	Homo sapiens	O94906	Y2H	12620389
Intra	ARAF	P10398	EFEMP1	Homo sapiens	Q12805	Y2H	12620389
Intra	ARAF	P10398	CPS1	Homo sapiens	P31327	Y2H	12620389
Intra	ARAF	P10398	ASS1	Homo sapiens	P00966	Y2H	12620389
Intra	ARAF	P10398	PBK	Homo sapiens	Q96KB5	Y2H	12620389
Intra	ARAF	P10398	NUDT14	Homo sapiens	O95848	Y2H	12620389
Intra	ARAF	P10398	TIMM44	Homo sapiens	O43615	Y2H	12620389
Intra	ARAF	P10398	IRF7	Homo sapiens	Q92985	Anti Tag CoIP	21903422

Cross: Cross-species interaction Intra: Intraspecies interaction

ARAF Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80018	A-RAF Antibody (YA614)	WB, ICC/IF, IHC-P, FC	Human, Mouse
HY-P82928	A-RAF Antibody (YA2673)	WB, IHC-P, ICC/IF, FC	Human
HY-P82928A	A-RAF Antibody (YA2673)(PBS only)	WB, IHC-P	Human

Related Diseases

Diseases	Alias
Pallister-Killian Syndrome	PKS Tetrasomy 12p, Mosaic Isochromosome 12p Syndrome Pallister-Killian Mosaic Syndrome Chromosome 12, Isochromosome 12p Syndrome Killian Teschler-Nicola Syndrome Killian Syndrome Pallister Killian Syndrome Pallister Mosaic Syndrome Teschler-Nicola Killian Syndrome Teschler-Nicola/Killian Syndrome Tetrasomy 12p Isochromosome 12p Mosaicism
Skin Melanoma	Cutaneous Melanoma Malignant Ear Melanoma Malignant Lip Melanoma Malignant Lower Limb Melanoma Malignant Melanoma Of Ear And/Or External Auricular Canal Malignant Melanoma Of Skin Of Lower Limb Malignant Melanoma Of Skin Of Trunk Except Scrotum Malignant Melanoma Of Skin Of Upper Limb Malignant Neck Melanoma Malignant Scalp Melanoma Malignant Trunk Melanoma Malignant Upper Limb Melanoma Melanoma, Cutaneous Malignant Melanoma Malignant Melanoma Of Skin Melanoma Nos Malignant Mole, Meaning Melanoma Of Unspecified Site Melanoma Of Unspecified Site Cutaneous Malignant Melanoma Mm - [Malignant Melanoma]
Mycobacterium Marinum	Mycobacterium Marinum Infection Fish Tank Granuloma M. Marinum
Renal Cell Carcinoma, Papillary, 1	Papillary Renal Cell Carcinoma Hereditary Papillary Renal Cell Carcinoma Papillary Renal Cell Carcinoma, Sporadic Papillary Renal Cell Adenocarcinoma RCCP RCCP1 Renal Cell Carcinoma, Papillary Renal Cell Carcinoma, Papillary, 1, Familial And Somatic Chromophil Carcinoma Of Kidney Papillary Kidney Carcinoma Sporadic Papillary Renal Cell Carcinoma Chromophil Renal Cell Carcinoma Papillary Renal Carcinoma, Malignant - Papillary Renal Cell Carcinoma, Bilateral - Papillary Renal Cell Carcinoma, Familial - Papillary Renal Cell Carcinoma, Multiple - Papillary Renal Cell Carcinoma, Sporadic - Renal Adenocarcinoma Chromophil Rcc Hprcc Renal Cell Carcinoma Papillary Chromophilic Renal Cell Carcinoma Prcc Carcinoma, Renal Cell, Papillary, Type 1 Type 1 Papillary Renal Cell Carcinoma Renal Cell Carcinoma Hereditary Papillary Renal Carcinoma
Lymphatic Malformation 12	Central Conducting Lymphatic Anomaly LMPHM12 Ccla Lymphatic Malformation-7 Doid:0081030
Histiocytosis	Chronic Histiocytosis X Hand Schuller Christian Disease Hand-Schüller-Christian Disease Histiocytic Syndrome Histiocytosis, Langerhans-Cell
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Non-Langerhans-Cell Histiocytosis	Histiocytosis, Non-Langerhans-Cell Non-Langerhans Cell Histiocytosis
Acneiform Dermatitis	Dermatitis Acneiform
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Hawkinsinuria	4-Alpha-Hydroxyphenylpyruvate Hydroxylase Deficiency 4-Hppd Deficiency 4-Hydroxyphenylpyruvic Acid Dioxygenase Deficiency HWKS HAWK
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Skin Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Skin Epidermoid Skin Carcinoma Squamous Cell Carcinoma Of The Skin Squamous Cell Epithelioma Of Skin Cutaneous Squamous Cell Carcinoma Scc - [Squamous Cell Carcinoma] Of Skin
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome
Langerhans Cell Histiocytosis	Histiocytosis X Lch Langerhans Cell Granulomatosis Langerhans-Cell Histiocytosis Letterer-Siwe Disease Hashimoto-Pritzger Disease Histiocytosis, Langerhans-Cell Langerhan'S Cell Histiocytosis Letterer-Siwe Disease Involving Intra-Abdominal Lymph Nodes Letterer-Siwe Disease Involving Intrapelvic Lymph Nodes Letterer-Siwe Disease Involving Intrathoracic Lymph Nodes Letterer-Siwe Disease Involving Lymph Nodes Of Axilla And Upper Limb Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face And Neck Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face, And Neck Letterer-Siwe Disease Involving Lymph Nodes Of Inguinal Region And Lower Limb Letterer-Siwe Disease Involving Lymph Nodes Of Multiple Sites Letterer-Siwe Disease Involving Spleen Letterer-Siwe Disease Of Intra-Abdominal Lymph Nodes Letterer-Siwe Disease Of Intrapelvic Lymph Nodes Letterer-Siwe Disease Of Intrathoracic Lymph Nodes Letterer-Siwe Disease Of Lymph Nodes Of Axilla And Upper Limb Letterer-Siwe Disease Of Lymph Nodes Of Axilla And/Or Upper Limb Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And Neck Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And/Or Neck Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region Amd/Or Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Multiple Sites Letterer-Siwe Disease Of Spleen Familial Letterer-Siwe Disease Langerhans-Cell Histiocytosis Nos
Cardiofaciocutaneous Syndrome 1	Cardiofaciocutaneous Syndrome Cfc Syndrome Cardio-Facio-Cutaneous Syndrome CFC1 Cfcs Cardio-Facial-Cutaneous Syndrome Congenital Heart Defects Characteristic Facial Appearance Ectodermal Abnormalities And Growth Failure Cardiofaciocutaneous Syndrome, Type 1
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Noonan Syndrome With Multiple Lentigines	Leopard Syndrome Multiple Lentigines Syndrome Moynahan Syndrome Cardiomyopathic Lentiginosis Progressive Cardiomyopathic Lentiginosis Cardio-Cutaneous Syndrome Lentiginosis Profusa Capute-Rimoin-Konigsmark-Esterly-Richardson Syndrome Generalized Lentiginosis Gorlin Syndrome Ii Lentiginosis Profusa Syndrome Lentigines, Electrocardiographic Conduction Abnormalities, Ocular Hypertelorism, Pulmonic Stenosis, Abnormal Genitalia, Retardation Of Growth, Deafnes Diffuse Lentiginosis Nsml Familial Multiple Lentigines Syndrome Alopecia-Epilepsy-Intellectual Disability Syndrome, Moynahan Type Progressive Cardiomyopathic Lentiginosis Syndrome Alopecia Epilepsy Oligophrenia Syndrome Of Moynahan
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Melanoma, Cutaneous Malignant 1	Familial Melanoma Melanoma, Cutaneous Malignant, Susceptibility To, 1 Melanoma, Malignant CMM1 Melanoma, Cutaneous Malignant Cmm Familial Atypical Mole-Malignant Melanoma Syndrome Fammm Melanoma, Familial Mlm Dysplastic Nevus Syndrome, Hereditary Dns B-K Mole Syndrome Melanoma, Cutaneous Malignant, 1 Malignant Melanoma, Cutaneous Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1 Dysplastic Nevus Syndrome Cutaneous Melanoma Familial Atypical Mole Melanoma Syndrome Hereditary Melanoma
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-158115	NST-628	Inhibitor	99.35%	Phase 1

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-181067	IK-595	Inhibitor	98.55%	Unkown
HY-162752	Anticancer agent 250		/	Unkown
HY-169869	pan-Raf/RTK inhibitor 1	Inhibitor	/	Unkown
HY-178042	SS-3091	Inhibitor	/	Unkown
HY-18652A	Avutometinib potassium	Inhibitor	/	Unkown
HY-E70103I	exo-α-1,3-Arabinofuranosidase, Penicillium chrysogenum		/	Unkown
HY-RS00886	ARAF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18462	Araf Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24943	Araf Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ARAF	VGNC	VGNC:69997
Canis familiaris	ARAF	VGNC	VGNC:38024
Rattus norvegicus	ARAF	RGD	RGD:2148
Bos taurus	ARAF	VGNC	VGNC:26054
Mus musculus	ARAF	MGD	MGI:88065
Felis catus	ARAF	VGNC	VGNC:67995
Others	ARAF	NCBI