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LY314228

LY314228 is an aminoguanidine 5-HT2 antagonist with relative selectivity for 5-HT2A receptors (IC50: 147.9 nM). The Ki values of LY314228 targeting different 5-HT subtypes are 65 nM (5-HT 2A), 1214 nM (5-HT 2B), and 168 nM (5-HT 2C), respectively. LY314228 is an effective inhibitor of 5-HT-induced paw edema in rats with an ED50 of 6.4 mg/kg in ovariectomized female rats..

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  • CAS No.: 182633-54-1
  • Formula: C20H24N4O3
  • Molecular Weight:368.43
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • LY314228 Chemical Structure
    LY314228 Chemical Structure
CAS No.: 182633-54-1
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All 5-HT Receptor Isoforms

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    LY314228 Chemical Structure
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