MD6a
MD6a is a melatonin derivative with inhibitroy activity towards PARP-1, which maintains proteins hemostasis and improves mitochondrial function through TOR/HSF-1 signaling. MD6a a neuroprotective effect.
For research use only. We do not sell to patients.
- Formula: C21H22N2O2
- Molecular Weight:334.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MD6a (10 μM) inhibits PARP-1 to downregulate let-363/hsf-1 signaling by targeting hsp-4 and hsp-6, thus reducing α-syn aggregation and enhances mitochondrial function in C. elegans[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:wildtype N2, NL5901, parp-1 RNAi
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Concentration:10 μM
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Incubation Time:48 h
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Result:Reduced levels of parp-1 mRNA, parp-1 dependent α-syn aggregation and mitochondrial ROS levels.
Chemical Information
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Molecular Weight 334.41
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Formula C21H22N2O2
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SMILES
COC1=CC(/C=C/C2=CC=CC=C2)=C(NC=C3CCNC(C)=O)C3=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MD6a Related Classifications
HY-162363 Related Classifications
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