Cat. No.: HY-N0128

Sclareol

3 Cited Publications

Customer Review

Based on 3 publication(s) in Google Scholar

Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB) cells and human leukemia cell lines. Sclareol induces cell apoptosis.

For research use only. We do not sell to patients.

Purity: 99.84%
CAS No.: 515-03-7
Formula: C₂₀H₃₆O₂
Molecular Weight:308.50

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Sclareol Chemical Structure

CAS No.: 515-03-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Publications (3)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.21 μM Compound: 1	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 25825934]
B16	IC₅₀	28 μg/mL Compound: 1	In vitro cytotoxicity of compound was measured on murine melanoma (B16) cells. In vitro cytotoxicity of compound was measured on murine melanoma (B16) cells.	[PMID: 9873721]
Cancer cell lines	IC₅₀	7 μg/mL Compound: 1, Sclareol	Cytotoxicity against human breast cancer cells Cytotoxicity against human breast cancer cells	[PMID: 22250858]
HCT-116	IC₅₀	10.6 μg/mL Compound: 1, Sclareol	Cytotoxicity against human HCT116 cells Cytotoxicity against human HCT116 cells	[PMID: 22250858]
HeLa	IC₅₀	3.35 μM Compound: 1	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 25825934]
HUVEC	IC₅₀	>50 μg/mL Compound: 4	Growth inhibitory activity against human umbilical vein endothelial cells (HUVEC) proliferation using MTT colorimetric method Growth inhibitory activity against human umbilical vein endothelial cells (HUVEC) proliferation using MTT colorimetric method	[PMID: 12781184]
Leukemia cell	IC₅₀	6 μg/mL Compound: 1, Sclareol	Cytotoxicity against human leukemia cells Cytotoxicity against human leukemia cells	[PMID: 22250858]
P388	IC₅₀	10.1 μg/mL Compound: 1	In vitro cytotoxicity of compound was measured on murine lymphocytic leukemia (P-388) cells. In vitro cytotoxicity of compound was measured on murine lymphocytic leukemia (P-388) cells.	[PMID: 9873721]
PBMC	IC₅₀	10.7 μg/mL Compound: 1, Sclareol	Cytotoxicity against human PBMC Cytotoxicity against human PBMC	[PMID: 22250858]
PC-3	IC₅₀	0.105 μM Compound: 1	Cytotoxicity against human PC3 cells after 48 hrs by MTT assay Cytotoxicity against human PC3 cells after 48 hrs by MTT assay	[PMID: 25825934]
SNU1	IC₅₀	11.9 μg/mL Compound: 1	In vitro cytotoxicity of compound was measured on human gastric adenocarcinoma (SNU-1) cells. In vitro cytotoxicity of compound was measured on human gastric adenocarcinoma (SNU-1) cells.	[PMID: 9873721]

In Vitro

Sclareol is cytotoxic to 13 of 14 human leukemia cell lines tested, with IC₅₀ values ranging from 6.0-24.2 μg/mL, but is not cytotoxic to peripheral blood mononuclear leukocytes within the same dose range^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 515-03-7
Appearance Solid
Molecular Weight 308.50
Formula C₂₀H₃₆O₂
Color White to off-white
SMILES

CC1(C)CCC[C@@]2(C)[C@@]1([H])CC[C@](O)(C)[C@@H]2CC[C@@](C)(O)C=C
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
- Plants
- Labiatae
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (3)

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Journal Impact Factor

Phytomedicine

Sclareol improves the pathology of Alzheimer's disease by inhibiting microglial inflammation via interacting with CDK9. [Abstract]

2025 Apr:139:156504. PMID: 39970859
Phytother Res

Sclareol attenuates liver fibrosis through SENP1-mediated VEGFR2 SUMOylation and inhibition of downstream STAT3 signaling. [Abstract]

2023 Sep;37(9):3898-3912. PMID: 37132081
Int Immunopharmacol

Sclareol can effectively ameliorate Feline calicivirus induced lung injury via the inhibition of inflammation and apoptosis. [Abstract]

2025 Oct 30:164:115342. PMID: 40795501

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (324.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.2415 mL

16.2075 mL

32.4149 mL

5 mM

0.6483 mL

3.2415 mL

6.4830 mL

10 mM

0.3241 mL

1.6207 mL

3.2415 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (8.10 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (8.10 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (8.10 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Robert Tisserand, et al. Sclareol.Constituent profiles

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.2415 mL	16.2075 mL	32.4149 mL	81.0373 mL
	5 mM	0.6483 mL	3.2415 mL	6.4830 mL	16.2075 mL
	10 mM	0.3241 mL	1.6207 mL	3.2415 mL	8.1037 mL
	15 mM	0.2161 mL	1.0805 mL	2.1610 mL	5.4025 mL
	20 mM	0.1621 mL	0.8104 mL	1.6207 mL	4.0519 mL
	25 mM	0.1297 mL	0.6483 mL	1.2966 mL	3.2415 mL
	30 mM	0.1080 mL	0.5402 mL	1.0805 mL	2.7012 mL
	40 mM	0.0810 mL	0.4052 mL	0.8104 mL	2.0259 mL
	50 mM	0.0648 mL	0.3241 mL	0.6483 mL	1.6207 mL
	60 mM	0.0540 mL	0.2701 mL	0.5402 mL	1.3506 mL
	80 mM	0.0405 mL	0.2026 mL	0.4052 mL	1.0130 mL
	100 mM	0.0324 mL	0.1621 mL	0.3241 mL	0.8104 mL

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Sclareol

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Publications Citing Use of MedChemExpress (MCE) Sclareol

Biological Activity

Chemical Information

Publications (3)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Sclareol Related Classifications

HY-N0128 Related Classifications