2. GPCR/G Protein
  3. Leukotriene Receptor
  4. NZ-107

NZ-107 is an orally active leukotriene receptor antagonist. NZ-107 can inhibit anaphylaxis reaction. NZ-107 can be used for the researches of inflammation and immunology.

For research use only. We do not sell to patients.

NZ-107

NZ-107 Chemical Structure

CAS No. : 107186-52-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
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NZ-107 Related Antibodies

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  • Biological Activity

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Description

NZ-107 is an orally active leukotriene receptor antagonist. NZ-107 can inhibit anaphylaxis reaction. NZ-107 can be used for the researches of inflammation and immunology[1].

In Vivo

NZ-107 (50 mg/kg for i.p. or 100 mg/kg for p.o.) suppresses 48-h homologous passive cutaneous anaphylaxis reaction and Histamine (HY-B1204)-, Leukotriene C4 (HY-113446)- and Leukotriene D4 (HY-113456)-induced skin reactions in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

354.20

Formula

C14H16BrN3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCOC1=C(C=CC(CNC2=C(C(NN=C2)=O)Br)=C1)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 35 mg/mL (98.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8233 mL 14.1163 mL 28.2326 mL
5 mM 0.5647 mL 2.8233 mL 5.6465 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8233 mL 14.1163 mL 28.2326 mL 70.5816 mL
5 mM 0.5647 mL 2.8233 mL 5.6465 mL 14.1163 mL
10 mM 0.2823 mL 1.4116 mL 2.8233 mL 7.0582 mL
15 mM 0.1882 mL 0.9411 mL 1.8822 mL 4.7054 mL
20 mM 0.1412 mL 0.7058 mL 1.4116 mL 3.5291 mL
25 mM 0.1129 mL 0.5647 mL 1.1293 mL 2.8233 mL
30 mM 0.0941 mL 0.4705 mL 0.9411 mL 2.3527 mL
40 mM 0.0706 mL 0.3529 mL 0.7058 mL 1.7645 mL
50 mM 0.0565 mL 0.2823 mL 0.5647 mL 1.4116 mL
60 mM 0.0471 mL 0.2353 mL 0.4705 mL 1.1764 mL
80 mM 0.0353 mL 0.1765 mL 0.3529 mL 0.8823 mL
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NZ-107 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NZ-107107186-52-7NZ107NZ 107Leukotriene ReceptorInhibitorinhibitorinhibit

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