CATPB
Based on 2 publication(s) in Google Scholar
CATPB is a potent, selective free fatty acid receptor 2 (FFA2R/GPR43) antagonist.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 1322598-09-3
- Formula: C19H17ClF3NO3
- Molecular Weight:399.79
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) CATPB
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Biological Activity
FFA2R(GPR43)[1]
CATPB inhibits the transient rise in intracellular Ca2+ induced in neutrophils by acetate or Cmp1 (FFAR2 agonist)[1].
CATPB inhibits Cmp1-induced NADPH oxidase activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1322598-09-3
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Appearance Solid
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Molecular Weight 399.79
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Formula C19H17ClF3NO3
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Color White to off-white
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SMILES
OC(C[C@H](CC1=CC=C(C=C1)C(F)(F)F)NC(CC2=CC=CC(Cl)=C2)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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J Hematol Oncol
2024 Feb 24;17(1):9. PMID: 38402237 -
Cancer Res
Mannose Enhances Immunotherapy Efficacy in Ovarian Cancer by Modulating Gut Microbial Metabolites. [Abstract]2025 Apr 17. PMID: 40245117
Solvent & Solubility
DMSO : 100 mg/mL (250.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.25 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.25 mM); Suspended solution
This protocol yields a suspended solution of ≥ 2.5 mg/mL (saturation unknown). Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5013 mL | 12.5066 mL | 25.0131 mL | 62.5328 mL |
| 5 mM | 0.5003 mL | 2.5013 mL | 5.0026 mL | 12.5066 mL | |
| 10 mM | 0.2501 mL | 1.2507 mL | 2.5013 mL | 6.2533 mL | |
| 15 mM | 0.1668 mL | 0.8338 mL | 1.6675 mL | 4.1689 mL | |
| 20 mM | 0.1251 mL | 0.6253 mL | 1.2507 mL | 3.1266 mL | |
| 25 mM | 0.1001 mL | 0.5003 mL | 1.0005 mL | 2.5013 mL | |
| 30 mM | 0.0834 mL | 0.4169 mL | 0.8338 mL | 2.0844 mL | |
| 40 mM | 0.0625 mL | 0.3127 mL | 0.6253 mL | 1.5633 mL | |
| 50 mM | 0.0500 mL | 0.2501 mL | 0.5003 mL | 1.2507 mL | |
| 60 mM | 0.0417 mL | 0.2084 mL | 0.4169 mL | 1.0422 mL | |
| 80 mM | 0.0313 mL | 0.1563 mL | 0.3127 mL | 0.7817 mL | |
| 100 mM | 0.0250 mL | 0.1251 mL | 0.2501 mL | 0.6253 mL |
CATPB Related Classifications
HY-116263 Related Classifications
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