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Cat. No.: HY-183046

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PAICS-IN-1

PAICS-IN-1 is a PAICS inhibitor. PAICS-IN-1 inhibits the bifunctional enzyme catalyzing the 6th and 7th steps of the de novo purine pathway. PAICS-IN-1 can be used for the research of cancer.

For research use only. We do not sell to patients.

CAS No.: 2231428-32-1
Formula: C₁₉H₂₇BrN₆O₄S
Molecular Weight:515.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PAICS-IN-1 Chemical Structure

CAS No.: 2231428-32-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

PAICS-IN-1 is a PAICS inhibitor. PAICS-IN-1 inhibits the bifunctional enzyme catalyzing the 6th and 7th steps of the de novo purine pathway. PAICS-IN-1 can be used for the research of cancer^[1].

All DNA/RNA Synthesis Isoforms :

In Vitro

PAICS-IN-1 (compound 69) potently inhibits PAICS in a cell-free biochemical assay with an IC₆₀ classified as class A^[1].
PAICS-IN-1 potently inhibits proliferation of unspecified cancer cells in a 2D cell proliferation assay with an EC₅₀ classified as class A^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2231428-32-1
Molecular Weight 515.42
Formula C₁₉H₂₇BrN₆O₄S
SMILES

O=C(C1=COC(N)=N1)NC2=CC(N3CCN(S(=O)(CCCN(C)C)=O)CC3)=CC=C2Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Simon Osborne, et al. Oxazole derivatives for use in the treatment of cancer. WO2018122549A1. 2017-12-19.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
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PAICS-IN-1

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PAICS-IN-1 Related Classifications

HY-183046 Related Classifications