PDE1-IN-8
PDE1-IN-8 (Compound 3f) is the inhibitor for PDE1 with an IC50 of 11 nM. PDE1-IN-8 inhibits cAMP and cGMP signaling pathway, inhibits the differentiation and proliferation of cells into myofibroblast, and exhibits anti-fibrotic efficacy in Bleomycin (HY-17565)-induced rat pulmonary fibrosis model.
For research use only. We do not sell to patients.
- Formula: C17H11Cl2N3OS2
- Molecular Weight:408.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PDE1C 11 nM (IC50) |
PDE1A 263 nM (IC50) |
PDE1B 357 nM (IC50) |
PDE5A 681 nM (IC50) |
PDE2A 1820 nM (IC50) |
PDE7A 2093 nM (IC50) |
PDE10A 2394 nM (IC50) |
PDE4D 3006 nM (IC50) |
PDE8A 3729 nM (IC50) |
PDE9A 4617 nM (IC50) |
PDE3A 5164 nM (IC50) |
Chemical Information
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Molecular Weight 408.32
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Formula C17H11Cl2N3OS2
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SMILES
ClC1=CC=CC(C(C)SC2=NC(C3=CC=C(S3)Cl)=C(C(N2)=O)C#N)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PDE1-IN-8 Related Classifications
HY-169963 Related Classifications
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