PDE1-IN-8
PDE1-IN-8 (Compound 3f) is the inhibitor for PDE1 with an IC50 of 11 nM. PDE1-IN-8 inhibits cAMP and cGMP signaling pathway, inhibits the differentiation and proliferation of cells into myofibroblast, and exhibits anti-fibrotic efficacy in Bleomycin (HY-17565)-induced rat pulmonary fibrosis model.
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- Formel: C17H11Cl2N3OS2
- Molecular Weight:408.32
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
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PDE1C 11 nM (IC50) |
PDE1A 263 nM (IC50) |
PDE1B 357 nM (IC50) |
PDE5A 681 nM (IC50) |
PDE2A 1820 nM (IC50) |
PDE7A 2093 nM (IC50) |
PDE10A 2394 nM (IC50) |
PDE4D 3006 nM (IC50) |
PDE8A 3729 nM (IC50) |
PDE9A 4617 nM (IC50) |
PDE3A 5164 nM (IC50) |
Chemical Information
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Molecular Weight 408.32
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Formel C17H11Cl2N3OS2
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SMILES
ClC1=CC=CC(C(C)SC2=NC(C3=CC=C(S3)Cl)=C(C(N2)=O)C#N)=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PDE1-IN-8 Related Classifications
HY-169963 Related Classifications
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