Phenylsulfamide

Cat. No.: HY-147353 Purity: 99.90%: Data Sheet
COA

SDS
Handling Instructions
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Phenylsulfamide (Compound 10) is a human carbonic anhydrase-II (hCA-II) inhibitor with a K_d of 45.50 μM and a K_i of 79.60 μM.

For research use only. We do not sell to patients.

Phenylsulfamide Chemical Structure

CAS No. : 15959-53-2

Size	Price	Stock
100 mg		Ask For Quote & Lead Time
250 mg		Ask For Quote & Lead Time
1 g		Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

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Biological Activity
Purity & Documentation
References
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Description

Phenylsulfamide (Compound 10) is a human carbonic anhydrase-II (hCA-II) inhibitor with a K_d of 45.50 μM and a K_i of 79.60 μM^[1].

IC₅₀ & Target

hCA II

45.50 μM (Kd)

hCA II

79.60 μM (Ki)

Molecular Weight

172.20

Formula

C₆H₈N₂O₂S

CAS No.

15959-53-2

Appearance

Solid

Color

White to light yellow

SMILES

O=S(N)(NC1=CC=CC=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (290.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.8072 mL	29.0360 mL	58.0720 mL
5 mM	1.1614 mL	5.8072 mL	11.6144 mL
10 mM	0.5807 mL	2.9036 mL	5.8072 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (272 KB) SDS (394 KB)

COA (249 KB) HNMR (154 KB) LCMS (324 KB)

Handling Instructions (2659 KB)

References

[1]. Klinger AL, et al. Inhibition of carbonic anhydrase-II by sulfamate and sulfamide groups: an investigation involving direct thermodynamic binding measurements. J Med Chem. 2006 Jun 15;49(12):3496-500. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.8072 mL	29.0360 mL	58.0720 mL	145.1800 mL
	5 mM	1.1614 mL	5.8072 mL	11.6144 mL	29.0360 mL
	10 mM	0.5807 mL	2.9036 mL	5.8072 mL	14.5180 mL
	15 mM	0.3871 mL	1.9357 mL	3.8715 mL	9.6787 mL
	20 mM	0.2904 mL	1.4518 mL	2.9036 mL	7.2590 mL
	25 mM	0.2323 mL	1.1614 mL	2.3229 mL	5.8072 mL
	30 mM	0.1936 mL	0.9679 mL	1.9357 mL	4.8393 mL
	40 mM	0.1452 mL	0.7259 mL	1.4518 mL	3.6295 mL
	50 mM	0.1161 mL	0.5807 mL	1.1614 mL	2.9036 mL
	60 mM	0.0968 mL	0.4839 mL	0.9679 mL	2.4197 mL
	80 mM	0.0726 mL	0.3630 mL	0.7259 mL	1.8148 mL
	100 mM	0.0581 mL	0.2904 mL	0.5807 mL	1.4518 mL