POL1-IN-1
Based on 1 Customer Validation
POL1-IN-1 is a class of RNA polymerase I inhibitors with broad-spectrum antiproliferative activity against tumor cells, while selectively inhibiting RNA polymerase I transcription. By blocking RNA polymerase I-mediated rRNA synthesis, POL1-IN-1 impairs ribosome biogenesis, thereby inhibiting tumor cell proliferation and inducing apoptosis. POL1-IN-1 can be used for the research of malignant tumors.
For research use only. We do not sell to patients.
- Purity: 98.05%
- CAS No.: 1822358-25-7
- Formula: C21H20N6
- Molecular Weight:356.42
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
More
Biological Activity
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RNA Polymerase |
POL1-IN-1 (Compound 3A) exhibits potent anti-proliferative activity against various cancer cell lines[1].
POL1-IN-1 selectively inhibits RNA Polymerase I (Pol I) transcription with potent activity (IC50 < 0.5 μM) in A375 melanoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1822358-25-7
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Appearance Solid
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Molecular Weight 356.42
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Formula C21H20N6
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Color Light yellow to yellow
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SMILES
N#CC1=CC2=C(N3C1=NC4=CC=CC=C43)N=C(N5C[C@@H](C)N[C@@H](C)C5)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (70.14 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8057 mL | 14.0284 mL | 28.0568 mL | 70.1420 mL |
| 5 mM | 0.5611 mL | 2.8057 mL | 5.6114 mL | 14.0284 mL | |
| 10 mM | 0.2806 mL | 1.4028 mL | 2.8057 mL | 7.0142 mL | |
| 15 mM | 0.1870 mL | 0.9352 mL | 1.8705 mL | 4.6761 mL | |
| 20 mM | 0.1403 mL | 0.7014 mL | 1.4028 mL | 3.5071 mL | |
| 25 mM | 0.1122 mL | 0.5611 mL | 1.1223 mL | 2.8057 mL | |
| 30 mM | 0.0935 mL | 0.4676 mL | 0.9352 mL | 2.3381 mL | |
| 40 mM | 0.0701 mL | 0.3507 mL | 0.7014 mL | 1.7535 mL | |
| 50 mM | 0.0561 mL | 0.2806 mL | 0.5611 mL | 1.4028 mL | |
| 60 mM | 0.0468 mL | 0.2338 mL | 0.4676 mL | 1.1690 mL |
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