POLRMT-IN-3
POLRMT-IN-3 is a photosensitive inhibitor of mitochondrial RNA polymerase (POLRMT). POLRMT-IN-3 is biologically inactive in the dark but rapidly releases the active parent compound LJ03 upon illumination with 405 nm light, enabling spatiotemporally precise inhibition of POLRMT. POLRMT-IN-3 exhibits antitumor activity and can be used in research on tumors such as pancreatic cancer and ovarian cancer.
For research use only. We do not sell to patients.
- Formula: C36H30FN3O7
- Molecular Weight:635.64
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
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RNA Polymerase |
POLRMT-IN-3 (Compound J5) (168 h) exhibits low antiproliferative activity against MIA PaCa-2 and HEK293T cells under dark conditions, with IC50 values of 9.900 μM and 7.358 μM, respectively[1].
POLRMT-IN-3 significantly suppresses the transcription levels of ND1, CytB, and COX1, as well as the protein levels of NDUFB8, UQCRC2, and MTCO1 in MIA PaCa-2 cells after 3 minutes of 405 nm light irradiation[1].
POLRMT-IN-3 (25-100 nM; 14 days) followed by 405 nm irradiation for 3 minutes exhibits a dose-dependent inhibitory effect on colony formation in MIA PaCa-2 cells [1].
POLRMT-IN-3 exhibits photo-dependent antiproliferative activity in A2780, HeLa, A431, MDA-MB-468, and HepG2 cells after 3 minutes of 405 nm light irradiation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Zebrafish (AB strain) treated CM-DiI labeled MIA PaCa-2 cells[1]
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Dosage:200 nM; 500 nM
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Administration:Aqueous exposure; followed by 3 min of 405 nm irradiation; 3 days
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Result:Showed no effect on tumor proliferation under dark conditions.
Elicited dose-dependent suppression of tumor growth with no apparent toxicity after 405 nm light irradiation for 3 min.
Chemical Information
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Molecular Weight 635.64
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Formula C36H30FN3O7
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SMILES
O=C1C=C(C2=CC=CC=C2C)C3=C(O1)C=C(O[C@H](C)C(N4CCN(CC5=C([N+]([O-])=O)C=C6OC7=CC=CC=C7C6=C5)CC4)=O)C(F)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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