2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. Promestriene

Promestriene 

Cat. No.: HY-108293 Purity: 99.91%
COA Handling Instructions

Promestriene is a synthetic diethyl-ether of estradiol and a locally effective estrogen. Promestriene has an efficient action on vaginal atrophy while it is minimally absorbed.

For research use only. We do not sell to patients.

Promestriene Chemical Structure

Promestriene Chemical Structure

CAS No. : 39219-28-8

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 88 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 88 In-stock
Solid
1 mg USD 38 In-stock
5 mg USD 80 In-stock
10 mg USD 125 In-stock
25 mg USD 245 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Promestriene Related Antibodies

Top Publications Citing Use of Products

View All Estrogen Receptor/ERR Isoform Specific Products:

View All Isoforms
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Promestriene is a synthetic diethyl-ether of estradiol and a locally effective estrogen. Promestriene has an efficient action on vaginal atrophy while it is minimally absorbed[1][2].

In Vitro

Promestriene is an analogue of oestradiol which is minimally absorbed and devoid of systemic effects when administered intravaginally, either as gynecological cream or capsules[2].
Topical Promestriene is minimally absorbed with chronic use and has been reported to significantly improve the symptoms of vaginal atrophy[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Promestriene Related Antibodies
Clinical Trial
Molecular Weight

328.49

Appearance

Solid

Formula

C22H32O2
CAS No.
SMILES

C[C@@]12[C@@H](OC)CC[C@@]1([H])[C@]3([H])CCC4=C(C=CC(OCCC)=C4)[C@@]3([H])CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (60.88 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0442 mL 15.2212 mL 30.4423 mL
5 mM 0.6088 mL 3.0442 mL 6.0885 mL
10 mM 0.3044 mL 1.5221 mL 3.0442 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2 mg/mL (6.09 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2 mg/mL (6.09 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Promestriene Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Promestriene39219-28-8Estrogen Receptor/ERRestradiolchronicsymptoms,vaginalatrophyoestrogendeficiencyInhibitorinhibitorinhibit

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