PROTAC AR Degrader-5
PROTAC AR Degrader-5 (compound A46) is a potent AR PROTACs degrader with an IC50 value of 49 nM. PROTAC AR Degrader-5 inhibits sebaceous plaque and induces hair regeneration.
(Pink: Androgen Receptor ligand (HY-169967); Blue: VHL ligand (HY-125845); Black: linker (HY-169966)).
For research use only. We do not sell to patients.
- CAS No.: 2703021-51-4
- Formula: C52H54F4N8O7S2
- Molecular Weight:1043.16
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
PROTAC AR Degrader-5 (5, 10, 30 mg/ml +DHT 30 mpk; 150 µL; Skin application; 2 times a day for 17 days) induces hair regeneration in C57BL/6N mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:7-8 weeks, 90-110g, Female Golden hamster[1]
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Dosage:100, 200, 400, 800 µg + 12 µg TP
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Administration:Skin application; daily for 21 days
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Result:Inhibited sebaceous plaque with the inhibition rate of 19.24%, 35.20%, 49.54%, 51.61% at 100, 200, 400, 800 µg, respectively.
Chemical Information
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CAS No. 2703021-51-4
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Molecular Weight 1043.16
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Formula C52H54F4N8O7S2
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SMILES
S=C1N(C2=C(C(C(F)(F)F)=C(C=C2)C#N)F)C(C(C)(N1C3=CN=C(C4=CC=C(C=C4)OCCCCOCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)=O)=O)C=C3)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC AR Degrader-5 Related Classifications
HY-160547 Related Classifications
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