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Cat. No.: HY-160547

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PROTAC AR Degrader-5

PROTAC AR Degrader-5 (compound A46) is a potent AR PROTACs degrader with an IC₅₀ value of 49 nM. PROTAC AR Degrader-5 inhibits sebaceous plaque and induces hair regeneration.
(Pink: Androgen Receptor ligand (HY-169967); Blue: VHL ligand (HY-125845); Black: linker (HY-169966)).

For research use only. We do not sell to patients.

CAS No.: 2703021-51-4
Formula: C₅₂H₅₄F₄N₈O₇S₂
Molecular Weight:1043.16

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

PROTAC AR Degrader-5 Chemical Structure

CAS No.: 2703021-51-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

PROTAC AR Degrader-5 (compound A46) is a potent AR PROTACs degrader with an IC₅₀ value of 49 nM. PROTAC AR Degrader-5 inhibits sebaceous plaque and induces hair regeneration^[1]. (Pink: Androgen Receptor ligand (HY-169967); Blue: VHL ligand (HY-125845); Black: linker (HY-169966)).

All PROTACs Isoforms :

In Vivo

PROTAC AR Degrader-5 (compound A46) (100, 200, 400, 800 µg + 12 µg TP; Skin application; daily for 21 days) inhibits sebaceous plaque in golden hamster^[1].
PROTAC AR Degrader-5 (5, 10, 30 mg/ml +DHT 30 mpk; 150 µL; Skin application; 2 times a day for 17 days) induces hair regeneration in C57BL/6N mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

7-8 weeks, 90-110g, Female Golden hamster^[1]
Dosage:

100, 200, 400, 800 µg + 12 µg TP
Administration:

Skin application; daily for 21 days
Result:

Inhibited sebaceous plaque with the inhibition rate of 19.24%, 35.20%, 49.54%, 51.61% at 100, 200, 400, 800 µg, respectively.

Chemical Information

CAS No. 2703021-51-4
Molecular Weight 1043.16
Formula C₅₂H₅₄F₄N₈O₇S₂
SMILES

S=C1N(C2=C(C(C(F)(F)F)=C(C=C2)C#N)F)C(C(C)(N1C3=CN=C(C4=CC=C(C=C4)OCCCCOCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)=O)=O)C=C3)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. YouZhi Tong, et al. Bifunctional compound, preparation method therefor, and use thereof. WO2021180160A1.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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