PROTAC ERα Degrader-6

Name: PROTAC ERα Degrader-6
Brand: MedChemExpress
SKU: HY-157765
Rating: 4.5 (0 reviews)

Cat. No.: HY-157765 Purity: 97.55%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

PROTAC ERα Degrader-6 (compound A2) is a potent PROTAC degrader of ERα, with IC₅₀ of 0.11 μM in MCE-7 cells. PROTAC ERα Degrader-6 has anti-tumor effect. PROTAC ERα Degrader-6 is a fluorescent probes with Em of 582 nm that enable real-time visualization of ERα protein degradation.

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PROTAC ERα Degrader-6 화학구조

CAS No. : 3065420-66-5

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All PROTACs Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All Estrogen Receptor/ERR Isoform Specific Products:

View All Isoforms

Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

ERα

0.12 μM (DC₅₀)

In Vitro

PROTAC ERα Degrader-6 (compound A2) displays exceptional anti-proliferative activity against MCF-7 cells (IC₅₀=0.11 μM)^[1].
PROTAC ERα Degrader-6 exhibits exceptional fluorescence imaging performance with λ = 582 nm^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

913.09

화학식

C₅₁H₅₆N₆O₈S

CAS No.

3065420-66-5

Appearance

Solid

Color

Brown to red

SMILES

O=C(N1C[C@H](O)C[C@H]1C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)[C@@H](NC(CCCCCCCOC4=C(C=CC(O)=C4)/C=C/C5=C/C(C6=CC(O)=CC=C6O5)=C(C#N)/C#N)=O)C(C)(C)C

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 50 mg/mL (54.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0952 mL	5.4759 mL	10.9518 mL
5 mM	0.2190 mL	1.0952 mL	2.1904 mL
10 mM	0.1095 mL	0.5476 mL	1.0952 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 97.55%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (251 KB) HNMR (159 KB) RP-HPLC (145 KB) LCMS (239 KB)

Handling Instructions (2659 KB)

References

[1]. Xiaohua Wang, et al. Fluorescence theranostic PROTACs for real-time visualization of ERα degradation. Eur J Med Chem. 2024 Feb 1:267:116184. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0952 mL	5.4759 mL	10.9518 mL	27.3796 mL
	5 mM	0.2190 mL	1.0952 mL	2.1904 mL	5.4759 mL
	10 mM	0.1095 mL	0.5476 mL	1.0952 mL	2.7380 mL
	15 mM	0.0730 mL	0.3651 mL	0.7301 mL	1.8253 mL
	20 mM	0.0548 mL	0.2738 mL	0.5476 mL	1.3690 mL
	25 mM	0.0438 mL	0.2190 mL	0.4381 mL	1.0952 mL
	30 mM	0.0365 mL	0.1825 mL	0.3651 mL	0.9127 mL
	40 mM	0.0274 mL	0.1369 mL	0.2738 mL	0.6845 mL
	50 mM	0.0219 mL	0.1095 mL	0.2190 mL	0.5476 mL