PROTAC Her3 Degrader-8
Based on 1 Customer Validation
PROTAC Her3 Degrader-8 (Compound PP2) is a Her3 PROTAC degrader. PROTAC Her3 Degrader-8 promotes the ubiquitination and degradation of Her3. PROTAC Her3 Degrader-8 can be used in the study of lung adenocarcinoma and ovarian cancer.
(Pink: HER3 ligand (HY-107450); Blue: VHL ligand (HY-170861); Black: linker).
For research use only. We do not sell to patients.
- Purity: 99.60%
- CAS No.: 2103331-95-7
- Formula: C49H55N11O6S
- Molecular Weight:926.10
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HER3 |
Chemical Information
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CAS No. 2103331-95-7
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Appearance Solid
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Molecular Weight 926.10
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Formula C49H55N11O6S
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Color White to light brown
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SMILES
NC1=C2C(C(C=C3)=CC(NC(C=C)=O)=C3OC4=CC=CC=C4)=NN(C(CC5)CCN5CC(N[C@H](C(C)(C)C)C(N(C[C@H]6O)[C@H](C6)C(NCC7=CC=C(C(SC=N8)=C8C)C=C7)=O)=O)=O)C2=NC=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (107.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (2.70 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0798 mL | 5.3990 mL | 10.7980 mL | 26.9949 mL |
| 5 mM | 0.2160 mL | 1.0798 mL | 2.1596 mL | 5.3990 mL | |
| 10 mM | 0.1080 mL | 0.5399 mL | 1.0798 mL | 2.6995 mL | |
| 15 mM | 0.0720 mL | 0.3599 mL | 0.7199 mL | 1.7997 mL | |
| 20 mM | 0.0540 mL | 0.2699 mL | 0.5399 mL | 1.3497 mL | |
| 25 mM | 0.0432 mL | 0.2160 mL | 0.4319 mL | 1.0798 mL | |
| 30 mM | 0.0360 mL | 0.1800 mL | 0.3599 mL | 0.8998 mL | |
| 40 mM | 0.0270 mL | 0.1350 mL | 0.2699 mL | 0.6749 mL | |
| 50 mM | 0.0216 mL | 0.1080 mL | 0.2160 mL | 0.5399 mL | |
| 60 mM | 0.0180 mL | 0.0900 mL | 0.1800 mL | 0.4499 mL | |
| 80 mM | 0.0135 mL | 0.0675 mL | 0.1350 mL | 0.3374 mL | |
| 100 mM | 0.0108 mL | 0.0540 mL | 0.1080 mL | 0.2699 mL |
PROTAC Her3 Degrader-8 Related Classifications
HY-153796 Related Classifications
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