2. Immunology/Inflammation
  3. NO Synthase
  4. Pulchinenoside K

Pulchinenoside K (Compound 4) is a triterpenoid saponin. Pulchinenoside K can be isolated from the roots of *Pulsatilla koreana*. Pulchinenoside K inhibits NO production. Pulchinenoside K can be used for the research of inflammatory diseases.

For research use only. We do not sell to patients.

Pulchinenoside K

Pulchinenoside K Chemical Structure

CAS No. : 1257378-28-1

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Pulchinenoside K Related Antibodies

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Description

Pulchinenoside K (Compound 4) is a triterpenoid saponin. Pulchinenoside K can be isolated from the roots of *Pulsatilla koreana*. Pulchinenoside K inhibits NO production. Pulchinenoside K can be used for the research of inflammatory diseases[1].

In Vitro

Pulchinenoside K (1-100 μM; 1 h pre-treatment + 24 h LPS co-incubation) significantly inhibits LPS-induced NO production in RAW 264.7 cells at concentrations of 1 μM and 10 μM, and a decrease in cell viability is observed at all tested concentrations[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pulchinenoside K Related Antibodies

Cell Viability Assay[1]

Cell Line: RAW 264.7 macrophage cells
Concentration: 1 μM, 10 μM, 100 μM
Incubation Time: 25 h (total: 1 h pre-treatment + 24 h LPS co-incubation)
Result: Reduced relative NO production to 79.1% with a cell viability of 87.5% at 1 μM (significantly reduced compared to LPS-only control, p < 0.05).
Reduced relative NO production to 63.1% with a cell viability of 74.5% at 10 μM (significantly reduced, p < 0.01).
Reduced relative NO production to 79.1% with a cell viability of 51.5% at 100 μM.
Molecular Weight

1367.53

Formula

C65H106O30
CAS No.
SMILES

C(O[C@@H]1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O)(=O)[C@]45[C@@]([C@@]6([C@@](C)(CC4)[C@@]7(C)[C@](CC6)([C@]8(C)[C@@](CC7)(C(C)(C)[C@@H](O[C@H]9[C@H](O[C@H]%10[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O%10)[C@@H](O)[C@@H](O[C@@H]%11O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%11O)CO9)CC8)[H])[H])[H])([C@H](C(C)=C)CC5)[H]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Pulchinenoside K Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pulchinenoside K1257378-28-1NO SynthaseNitric oxide synthasesNOSlipopolysaccharidemacrophagesRAW 264.7 cellslupane-type triterpenoidal saponinPulsatilla koreananitric oxideInhibitorinhibitorinhibit

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