2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. (±)-E-Homocamptothecin

(±)-E-Homocamptothecin (BN 80245) is a topoisomerase I inhibitor. (±)-E-Homocamptothecin can be used for the research of cancer.

For research use only. We do not sell to patients.

(±)-E-Homocamptothecin

(±)-E-Homocamptothecin Chemical Structure

CAS No. : 186668-40-6

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(±)-E-Homocamptothecin Related Antibodies

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Description

(±)-E-Homocamptothecin (BN 80245) is a topoisomerase I inhibitor. (±)-E-Homocamptothecin can be used for the research of cancer[1].

IC50 & Target[1]

Topoisomerase I

 

Cellular Effect
Cell Line Type Value Description References
A-427 IC50
12 nM
Compound: 9a
Antiproliferative activity measured against A427 human lung carcinoma
Antiproliferative activity measured against A427 human lung carcinoma
[PMID: 9876111]
A-427 IC50
12 nM
Compound: rac-13, BN80245
Cytotoxicity against human A427 cells by WST assay
Cytotoxicity against human A427 cells by WST assay
[PMID: 23578545]
K562 IC50
47 nM
Compound: 9a
Antiproliferative activity measured against K562adr leukemia cells.
Antiproliferative activity measured against K562adr leukemia cells.
[PMID: 9876111]
L1210 IC50
16.2 nM
Compound: BN 80245
Compound was evaluated for cytotoxic activity on L1210 murine leukemia cells
Compound was evaluated for cytotoxic activity on L1210 murine leukemia cells
10.1016/S0960-894X(97)00398-3
MCF7 IC50
21 nM
Compound: 9a
Antiproliferative activity measured against MCF-7-mdr cells.
Antiproliferative activity measured against MCF-7-mdr cells.
[PMID: 9876111]
PC-3 IC50
60 nM
Compound: 9a
Antiproliferative activity measured against PC-3 human prostate adenocarcinoma
Antiproliferative activity measured against PC-3 human prostate adenocarcinoma
[PMID: 9876111]
Molecular Weight

362.38

Formula

C21H18N2O4
CAS No.
SMILES

O=C1OCC2=C(C(C1)(CC)O)C=C(C3=C(C4)C=C5C=CC=CC5=N3)N4C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(±)-E-Homocamptothecin Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(±)-E-Homocamptothecin186668-40-6BN 80245BN80245BN-80245TopoisomeraseInhibitorinhibitorinhibit

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