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Cat. No.: HY-131540

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(±)-E-Homocamptothecin

(Synonyms: BN 80245)

(±)-E-Homocamptothecin (BN 80245) is a topoisomerase I inhibitor. (±)-E-Homocamptothecin can be used for the research of cancer.

For research use only. We do not sell to patients.

CAS No.: 186668-40-6
Formula: C₂₁H₁₈N₂O₄
Molecular Weight:362.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

(±)-E-Homocamptothecin Chemical Structure

CAS No.: 186668-40-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

(±)-E-Homocamptothecin (BN 80245) is a topoisomerase I inhibitor. (±)-E-Homocamptothecin can be used for the research of cancer^[1].

IC₅₀ & Target^[1]

Topoisomerase I

All Topoisomerase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A-427	IC₅₀	12 nM Compound: 9a	Antiproliferative activity measured against A427 human lung carcinoma Antiproliferative activity measured against A427 human lung carcinoma	[PMID: 9876111]
A-427	IC₅₀	12 nM Compound: rac-13, BN80245	Cytotoxicity against human A427 cells by WST assay Cytotoxicity against human A427 cells by WST assay	[PMID: 23578545]
K562	IC₅₀	47 nM Compound: 9a	Antiproliferative activity measured against K562adr leukemia cells. Antiproliferative activity measured against K562adr leukemia cells.	[PMID: 9876111]
L1210	IC₅₀	16.2 nM Compound: BN 80245	Compound was evaluated for cytotoxic activity on L1210 murine leukemia cells Compound was evaluated for cytotoxic activity on L1210 murine leukemia cells	10.1016/S0960-894X(97)00398-3
MCF7	IC₅₀	21 nM Compound: 9a	Antiproliferative activity measured against MCF-7-mdr cells. Antiproliferative activity measured against MCF-7-mdr cells.	[PMID: 9876111]
PC-3	IC₅₀	60 nM Compound: 9a	Antiproliferative activity measured against PC-3 human prostate adenocarcinoma Antiproliferative activity measured against PC-3 human prostate adenocarcinoma	[PMID: 9876111]

Chemical Information

CAS No. 186668-40-6
Molecular Weight 362.38
Formula C₂₁H₁₈N₂O₄
SMILES

O=C1OCC2=C(C(C1)(CC)O)C=C(C3=C(C4)C=C5C=CC=CC5=N3)N4C2=O
Synonyms

BN 80245
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lavergne O, et al. BN 80245: an E-ring modified camptothecin with potent antiproliferative and topoisomerase I inhibitory activities[J]. Bioorganic & Medicinal Chemistry Letters, 1997, 7(17): 2235-2238.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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(±)-E-Homocamptothecin

All Topoisomerase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(±)-E-Homocamptothecin Related Classifications

HY-131540 Related Classifications