2. Membrane Transporter/Ion Channel Neuronal Signaling
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  4. Ro 48-8587

Ro 48-8587 is a selective AMPA receptor antagonist with an IC50 of 8 nM. Ro 48-8587 functionally inhibits AMPA receptor activity, blocks AMPA-induced depolarization of rat cortical wedges. Ro 48-8587 can be used for the research of ischaemia and seizures.

For research use only. We do not sell to patients.

Ro 48-8587

Ro 48-8587 Chemical Structure

CAS No. : 211120-62-6

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Ro 48-8587 Related Antibodies

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Description

Ro 48-8587 is a selective AMPA receptor antagonist with an IC50 of 8 nM. Ro 48-8587 functionally inhibits AMPA receptor activity, blocks AMPA-induced depolarization of rat cortical wedges. Ro 48-8587 can be used for the research of ischaemia and seizures[1].

IC50 & Target[1]

AMPA Receptor

8 nM (IC50)

In Vitro

Ro 48-8587 (1-2 h) potently inhibits [3H]AMPA, [3H]kainate and [3H]MK-801 binding to rat whole brain membranes with Ki values of 0.008, 1.3 and 8 μM[1].
Ro 48-8587 (1-10 μM) potently, competitively inhibits S-AMPA-induced depolarizations in rat brain cortical wedges with an IC50 of 0.089 μM[1].
Ro 48-8587 inhibits NMDA-induced depolarizations in rat brain cortical wedges with an IC50 of 4.4 μM[1].
Ro 48-8587 (0.5-50 nM; 1 h) binds to a single population of high-affinity sites on rat whole brain membranes with a KD of 3 ± 1 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ro 48-8587 Related Antibodies
In Vivo

Ro 48-8587 is moderately neuroprotective in a rat focal ischaemia model, reducing cortical infarct volume by 22%[1].
Ro 48-8587 7 prevents electroshock-induced convulsions or sound-induced seizures in MORO or DBA-2 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

313.23

Formula

C12H7N7O4
CAS No.
SMILES

O=C1NN2C(NC3=C(C=C(N4C=CN=C4)C([N+]([O-])=O)=C3)C2=N1)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ro 48-8587 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ro 48-8587211120-62-6iGluRIonotropic glutamate receptorsrat cortical wedgescerebellar molecular layerrat CNS regionsratreticular thalamic nucleusdorsal septumcortical layersbrain ischaemiastriatumAMPA receptorInhibitorinhibitorinhibit

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