RORγt inverse agonist 35
RORγt inverse agonist 35 (Compound 22) is a RORγt inverse agonist with an IC50 of 1.51 μM. RORγt inverse agonist 35 significantly inhibits Th17 differentiation and proinflammatory properties in human CD4+ T cells. RORγt inverse agonist 35 can be used for research of Th17-driven autoimmune diseases, such as psoriasis, multiple sclerosis, and inflammatory bowel disease (IBD).
For research use only. We do not sell to patients.
- Formula: C25H23FN2O3S
- Molecular Weight:450.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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RORγt 1.51 μM (IC50) |
IL-17A |
IL-17F |
IL-22 |
IL-21 |
Chemical Information
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Molecular Weight 450.53
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Formula C25H23FN2O3S
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SMILES
CC(S(=O)(C1=CC=C(C=C1)C2=CN3C=C(C=C3C=C2)C(NCC4=CC=C(C=C4)F)=O)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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