1. GPCR/G Protein
    Neuronal Signaling
    Membrane Transporter/Ion Channel
    Apoptosis
  2. Leukotriene Receptor
    Calcium Channel
    Apoptosis
  3. (S)-Verapamil hydrochloride

(S)-Verapamil hydrochloride (Synonyms: (S)-(-)-Verapamil hydrochloride)

Cat. No.: HY-135336A
Handling Instructions

(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells.

For research use only. We do not sell to patients.

(S)-Verapamil hydrochloride Chemical Structure

(S)-Verapamil hydrochloride Chemical Structure

CAS No. : 36622-28-3

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Description

(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells[1].

IC50 & Target[1]

LTC4

 

Ca2+

 

In Vitro

(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) not the (R)-Verapamil hydrochloride potently induces the death of MRP1-transfected BHK-21 cells[1].
(S)-Verapamil hydrochloride is good active form and has the low bioavailability[1].

Molecular Weight

491.06

Formula

C₂₇H₃₉ClN₂O₄

CAS No.

36622-28-3

SMILES

COC1=C(OC)C=CC(CCN(C)CCC[[email protected]@](C#N)(C2=CC(OC)=C(OC)C=C2)C(C)C)=C1.Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

(S)-Verapamil(S)-(-)-VerapamilLeukotriene ReceptorCalcium ChannelApoptosisCa2+ channelsCa channelscalceintransportMRP1tumorcellsactivebioavailabilityInhibitorinhibitorinhibit

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(S)-Verapamil hydrochloride
Cat. No.:
HY-135336A
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