1. GPCR/G Protein
    Neuronal Signaling
    Membrane Transporter/Ion Channel
    Apoptosis
  2. Leukotriene Receptor
    Calcium Channel
    Apoptosis
  3. (S)-Verapamil hydrochloride

(S)-Verapamil hydrochloride (Synonyms: (S)-(-)-Verapamil hydrochloride)

Cat. No.: HY-135336A Purity: 99.39% ee.: 99.39%
Handling Instructions

(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells.

For research use only. We do not sell to patients.

(S)-Verapamil hydrochloride Chemical Structure

(S)-Verapamil hydrochloride Chemical Structure

CAS No. : 36622-28-3

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10 mM * 1 mL in DMSO USD 270 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
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10 mg USD 450 In-stock
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50 mg USD 1400 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (S)-Verapamil hydrochloride:

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Description

(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells[1][2].

IC50 & Target[1]

LTC4

 

Ca2+

 

In Vitro

(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) not the (R)-Verapamil hydrochloride potently induces the death of MRP1-transfected BHK-21 cells[1].
(S)-Verapamil hydrochloride is good active form and has the low bioavailability[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

491.06

Formula

C₂₇H₃₉ClN₂O₄

CAS No.

36622-28-3

SMILES

COC1=C(OC)C=CC(CCN(C)CCC[[email protected]@](C#N)(C2=CC(OC)=C(OC)C=C2)C(C)C)=C1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (407.28 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0364 mL 10.1821 mL 20.3641 mL
5 mM 0.4073 mL 2.0364 mL 4.0728 mL
10 mM 0.2036 mL 1.0182 mL 2.0364 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (10.18 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5 mg/mL (10.18 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (10.18 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

(S)-Verapamil(S)-(-)-VerapamilLeukotriene ReceptorCalcium ChannelApoptosisCa2+ channelsCa channelscalceintransportMRP1tumorcellsactivebioavailabilityInhibitorinhibitorinhibit

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Product Name:
(S)-Verapamil hydrochloride
Cat. No.:
HY-135336A
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