Nucleotide Analogs

Uridine triphosphate (UTP; Uridine 5'-triphosphate) is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate activates membrane-bound P2Y2 receptors.

GDP-azido-fucose disodium is a glycoengineering tool. GDP-azido-fucose disodium modifies complex glycans by adding an azido-fucose group. GDP-azido-fucose disodium can install azido-fucose tags on antibody Fc glycans for site-specific payload conjugation, thereby forming antibody-drug conjugates with defined ratios.

7-Deaza-7-propargylamino-dATP TEA is an analog of deoxyadenosine triphosphate (dATP) that can be used for gene sequencing.

Gp(2′-5′)Ap sodium is a linear dinucleotide analog after hydrolysis of cyclic guanosine monophosphate- adenosine monophosphate (2’3’-cGAMP) by phosphodiesterases. Due to its linear conformation, 2’5’GpAp is intended to serve as a negative control for 2’3’-cGAMP in type I IFN induction assays.

5-Fluoro-2′-deoxy-UTP can be used as a substrate for DNA synthesis.

2′-Deoxyadenosine 5′-monophosphate disodium, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2′-Deoxyadenosine 5′-monophosphate disodium can be used to study adenosine-based interactions during DNA synthesis and DNA damage.

6-Thioinosine Phosphate (Thioinosinic acid) is an intermediate metabolite of azathioprine (HY-B0256). Azathioprine is a purine analog immunosuppressive drug.

Adenosine 5′-monophosphoramidate sodium is an adenosine derivative and can be used as an intermediate for nucleotide synthesis. Adenosine 5′-monophosphoramidate has a significant effect on the accumulation of cyclic AMP.

2'-O-POM-rA(Bz) is a monomeric raw material that can be used for nucleic acid synthesis.

3'-NH2-ddA (3'-Amino-2',3'-dideoxyadenosine) is a monomeric raw material that can be used for nucleic acid synthesis.

N4-Benzoyl-2'-fluoro-2'-deoxycytidine is a monomeric raw material that can be used for nucleic acid synthesis.

Uridine 3′,5′-diphosphate (3′,5′-UDP; Compound pUp) is a competitive RNase inhibitor.

Adenosine 5'-diphosphate dicyclohexylammonium is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate dicyclohexylammonium induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P2T-purinoceptors.

VP-U-6 is a nucleoside analog that can be used in oligonucleotide synthesis.

8-Bromoadenosine 5'-triphosphate tetrasodium (8-Br-ATP tetrasodium) is an ATP analogue. ATP is a central component of energy storage and metabolism in vivo.

5-F-UTP (5-Fluorouridine-5'-triphosphate) trisodium is a monomeric raw material that can be used for nucleic acid synthesis.

Fluorescein-12-dUTP is a fluorescent labeling and detection reagent that can be used for nucleic acid synthesis. Fluorescein-12-dUTP can be used to synthesize labeled DNA probes for in situ hybridization, microarray or western blot analysis.

5-Propargylamino-3'-azidomethyl-dCTP (TEA) is a nucleotide molecule that can be used in DNA synthesis and DNA sequencing. For detailed information, refer to compound 17 in patent document WO2004018497A2. 5-Propargylamino-3'-azidomethyl-dCTP (TEA) is a click chemistry reagent containing an azide group, which can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also react with molecules containing DBCO or BCN groups through strain-promoted alkyne-azide cycloaddition (SPAAC).

2-5A pentasodium solution (100 mM) (2′,5′-ApApA pentasodium solution (100 mM)) is a 5'-triphosphorylated (2',5') oligoadenylate. When covalently linked to an antisense molecule complementary to the target sequence, 2-5A pentasodium solution (100 mM) activates RNase L, which subsequently degrades the target RNA bound to the 2-5A pentasodium solution (100 mM) chimera. 2-5A pentasodium solution (100 mM) can be used in research related to respiratory syncytial virus infection, colorectal adenocarcinoma and melanoma.

Diguanosine 5′-triphosphate (Gp3G) triammonium is a dinucleoside triphosphates. Diguanosine 5′-triphosphate triammonium also is a virus-specific oligonucleotide. Diguanosine 5′-triphosphate triammonium is needed for the synthesis of RNA during the transcription process.