Nucleotide Analogs

2'-Deoxyinosine 5'-monophosphate (disodium) is a kind of biochemical reagent.

Cytidine 5′-triphosphate is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii.

Cytidine 5'-diphosphate (Cytidine) disodium salt is a nucleoside diphosphate that acts as a carrier for phosphorylcholine, diacylglycerol, and other molecules during phospholipid synthesis.

Adenosine 5′-O-(1-thiotriphosphate) is an α-Phosphate modified adenosine nucleotide.

Pseudouridine 5'-triphosphate (Pseudo-UTP) is a modified ribonucleoside triphosphate and uracil base-modified UTP derivative. Pseudouridine 5'-triphosphate enhances translational properties and stability of mRNA, reduces innate immune responses in mammalian cells, and inhibits signal-dependent transcription termination of vaccinia virus early gene transcription while supporting transcription elongation. Pseudouridine 5'-triphosphate can be used for the research of vaccinia virus infection.

N4-Acetylcytidine triphosphate is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription and can be incorporated into multiple templates.

Diadenosine pentaphosphate (Ap5A; P1,P5-Di(adenosine-5'-)pentaphosphate) pentaammonium is an endogenous generated diadenosine polyphosphate, possessing the dual identities of intracellular alarm signal and extracellular signaling molecule. Diadenosine pentaphosphate regulates calcium signaling in the nervous, cardiac and peripheral sensory systems by activating P2X1/P2X3/P2Y receptor and RyR2 channels (EC₅₀ = 140 μM). Diadenosine pentaphosphate can be used in studies related to intracellular calcium release channels, cardiovascular diseases and nociception (pain).

Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K⁺ channel. Guanosine 5'-diphosphate is an iron mobilizer, which forms a complex with hepcidin to inhibit the hepcidin-ferroportin (FPN) interaction and modulates the IL-6/stat-3 pathway. Guanosine 5'-diphosphate ameliorates the Turpentine-induced anemia of inflammation (AI) in mice when combined with FeSO₄. Guanosine 5'-diphosphate can be used in the research of AI.

Biotin-7-GMP (5'-Biotin-G-monophosphate) is a 5'-biotinylated guanosine monophosphate reagent. Biotin-7-GMP covalently links biotin to specific positions (G bases) of RNA molecules, enabling efficient and specific purification and detection of target RNAs through the ultra-stable binding between biotin and streptavidin.

Deoxythymidine-5'-triphosphate (dTTP) is a deoxyribonucleoside triphosphate and a thymidine analog, which serves as a direct precursor for DNA synthesis. Deoxythymidine-5'-triphosphate can be used for DNA amplification in the DNA polymerase chain reaction (PCR). Deoxythymidine-5'-triphosphate is also applicable to research related to diseases such as leukemia.

3',5'-UpU (3',5'-Uridylyluridine) is a 3',5'-linked uridylyluridine dinucleotide. 3',5'-UpU undergoes cyclization/cleavage reactions to form uridine and uridine 2',3'-cyclic phosphate, and can also isomerize into 2',5'-UpU. Under the consecutive acid-base bifunctional catalysis of imidazole buffer, 3',5'-UpU undergoes cyclization/cleavage reactions via a phosphorane intermediate.

2'-Deoxy-N-methyl-AMP ammonium is an N6-substituted adenine nucleotide derivative and a glycosyl donor. On one hand, 2'-Deoxy-N-methyl-AMP ammonium acts as a specific substrate for N6-methyl-AMP aminohydrolase, and it is catalytically converted to dIMP to participate in the nucleotide metabolic cycle. On the other hand, 2'-Deoxy-N-methyl-AMP ammonium also serves as a guanosine diphosphate (GDP)-linked fucose derivative donor, driving site-specific glycoconjugation of proteins under the mediation of α-1,3-fucosyltransferase. 2'-Deoxy-N-methyl-AMP ammonium is an important molecular tool for investigating the mechanisms of nucleotide modification and protein glycosylation.

Dicytidine 5′-triphosphate (Cp3C) trisodium is a cytosine-containing dinucleoside polyphosphate. Dicytidine 5′-triphosphate trisodium inhibits the intracellular accumulation of trans-resveratrol and trans-piceid. Dicytidine 5′-triphosphate trisodium induces the expression of CCR2 and upregulates the expression of PAL1 and 4CL1.

GDP-azido-fucose is a glycoengineering tool. GDP-azido-fucose modifies complex glycans by adding an azido-fucose group. GDP-azido-fucose can install azido-fucose tags on antibody Fc glycans for site-specific payload conjugation, thereby forming antibody-drug conjugates with defined ratios.

6-Chloropurine-2'-deoxyriboside is a monomeric raw material that can be used for nucleic acid synthesis.

Im-GDP is a monomeric raw material that can be used for nucleic acid synthesis.

7-Deaza-2'-dG (7-Deaza-2'-deoxyguanosine) is a monomeric raw material that can be used for nucleic acid synthesis.

2'-O-TBDMS-rG(iBu) is a monomeric raw material that can be used for nucleic acid synthesis.

5-F-UTP (5-Fluorouridine-5'-triphosphate) is a monomeric raw material that can be used for nucleic acid synthesis.

3'-NH2-CTP is a nucleotide analog with an amino group modified at the 3' end of CTP.