SAR156497
SAR156497 (compound 47) is an Aurora inhibitor, with IC50 values of 0.6 nM and 1 nM for Aurora A and Aurora B, respectively. SAR156497 can also inhibit PDE3, with IC50 value of 4 μM. SAR156497 can be used in anticancer research.
For research use only. We do not sell to patients.
- CAS No.: 1256137-14-0
- Formula: C27H24N4O4
- Molecular Weight:468.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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All Aurora Kinase Isoforms
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Biological Activity
Description
IC50 & Target
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PDE3 4 μM (IC50) |
Aurora A 0.6 nM (IC50) |
Aurora B 1 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
3.714 μM
Compound: SAR156497
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Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
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[PMID: 28818446] |
| HEK293 | IC50 |
5.864 μM
Compound: SAR156497
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Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
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[PMID: 28818446] |
| HeLa | IC50 |
0.00611 μM
Compound: SAR156497
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Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
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[PMID: 28818446] |
| HeLa | IC50 |
67 nM
Compound: 47
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Antiproliferative activity against human HeLa cells assessed as 14C-thymidine incorporation by Micro-Beta radioactivity counting analysis
Antiproliferative activity against human HeLa cells assessed as 14C-thymidine incorporation by Micro-Beta radioactivity counting analysis
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[PMID: 25369539] |
| PBMC | IC50 |
>10 μM
Compound: 47
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Cytotoxicity against human hematological tumor PBMC assessed as viability after 96 hrs by MTS assay
Cytotoxicity against human hematological tumor PBMC assessed as viability after 96 hrs by MTS assay
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[PMID: 25369539] |
| PC-3 | IC50 |
12.58 μM
Compound: SAR156497
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Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
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[PMID: 28818446] |
Chemical Information
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CAS No. 1256137-14-0
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Molecular Weight 468.50
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Formula C27H24N4O4
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SMILES
O=C1C([C@@H](C2=CC(OC3=NC4=CC=CC=C4N3)=CC=C2)C5=CN6)=C(CCC1)NC5=C6C(OCC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SAR156497 Related Classifications
HY-12476 Related Classifications
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