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Cat. No.: HY-B0210C

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Cefoperazone dihydrate

Name: Cefoperazone dihydrate
Brand: MedChemExpress
SKU: HY-B0210C
Availability: PreOrder

7 Cited Publications

Customer Review

Based on 7 publication(s) in Google Scholar

Cefoperazone dihydrate, a semisynthetic cephalosporin, has a broad spectrum of antibacterial activity.

For research use only. We do not sell to patients.

CAS No.: 113826-44-1
Formula: C₂₅H₃₁N₉O₁₀S₂
Molecular Weight:681.70

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Cefoperazone dihydrate Chemical Structure

CAS No.: 113826-44-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (7)
Protocols (2)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cefoperazone dihydrate, a semisynthetic cephalosporin, has a broad spectrum of antibacterial activity^[1].

IC₅₀ & Target

β-lactam

All Antibiotic Isoforms :

In Vitro

Cefoperazone (Aerosol treatment, 60 μg/mL final concentration in lung homogenate) protects granulocytopenic mice from acute Pseudomonas aeruginosa pneumonia^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 113826-44-1
Molecular Weight 681.70
Formula C₂₅H₃₁N₉O₁₀S₂
SMILES

O=C(C(N12)=C(CSC3=NN=NN3C)CS[C@]2([H])[C@H](NC([C@H](NC(N4C(C(N(CC)CC4)=O)=O)=O)C5=CC=C(O)C=C5)=O)C1=O)O.O.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (7)

All Bio/Physico-chemical AssayMicrobiological Assay

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Journal Impact Factor

Signal Transduct Target Ther

Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]

2025 Dec 15;10(1):406. PMID: 41392286
Carbohydr Polym

Preparation of bacterial cellulose-based antibacterial membranes with prolonged release of drugs: Emphasis on the chemical structure of drugs. [Abstract]

2024 Jan 1:323:121379. PMID: 37940275

Cefoperazone dihydrate purchased from MedChemExpress. Usage Cited in: Carbohydr Polym. 2024 Jan 1:323:121379. [Abstract]

According to the results, BC-CEF (Cefoperazone) had a loading quantity that was much higher than BC-CEF/Na.

Cefoperazone dihydrate purchased from MedChemExpress. Usage Cited in: Carbohydr Polym. 2024 Jan 1:323:121379. [Abstract]

The drug release profiles of CEF (Cefoperazone) and CEF/Na from membranes in PBS.

Cefoperazone dihydrate purchased from MedChemExpress. Usage Cited in: Carbohydr Polym. 2024 Jan 1:323:121379. [Abstract]

The antibacterial effectiveness of the BC-CEF (Cefoperazone) and BC-CEF/Na membranes against S. aureus and E. coli was very high.
Mol Med

Dexmedetomidine alleviates intestinal ischemia/reperfusion injury by modulating intestinal neuron autophagy and mitochondrial homeostasis via Nupr1 regulation. [Abstract]

2024 Nov 6;30(1):203. PMID: 39508252
Virulence

Antibacterial efficacy and mechanism of the novel antimicrobial peptide lachnospirin-1 against Acinetobacter baumannii. [Abstract]

2026 Dec 31;17(1):2646808. PMID: 41838520
Ther Adv Med Oncol

Repurposing of ivacaftor shows potential to treat ROR1 expressing high-grade serous ovarian cancer. [Abstract]

2026 Jan 2:18:17588359251409010. PMID: 41487693
Toxicol Appl Pharmacol

Role of microbial microbes in arsenic bioaccumulation and biotransformation in mice. [Abstract]

2023 Apr 1:464:116447. PMID: 36889513
J Antibiot (Tokyo)

Impact of short chain fatty acids (SCFAs) on antimicrobial activity of new β-lactam/β-lactamase inhibitor combinations and on virulence of Escherichia coli isolates. [Abstract]

2023 Apr;76(4):225-235. PMID: 36726014

Cefoperazone dihydrate purchased from MedChemExpress. Usage Cited in: J Antibiot (Tokyo). 2023 Apr;76(4):225-235. [Abstract]

Susceptibility patterns of E. coli isolates (n = 140) towards different β-Lactams singly and in combination with β-Lactamase inhibitors (CFP Cefoperazone, CAZ Ceftazidime, FEP Cefepime).

Protocols

All Signal Pathway Related Cell Biology

Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Bacterial live/dead nucleic-acid viability staining
The LIVE/DEAD bacterial viability staining method is based on differential permeability of nucleic-acid-binding fluorescent dyes, most commonly SYTO 9 and propidium iodide (PI), which enables discrimination of bacterial populations with intact versus compromised cytoplasmic membranes. SYTO 9 penetrates both intact and damaged bacterial membranes and binds nucleic acids to produce green fluorescence, whereas propidium iodide penetrates only cells with compromised membranes and fluoresces red while also reducing SYTO 9 signal through competitive binding and fluorescence interactions. The resulting fluorescence pattern is interpreted as a proxy for membrane integrity, which is widely used as an indicator of bacterial viability in microscopy, flow cytometry, and spectroscopic platforms. However, mechanistic studies show that SYTO 9 and PI interactions involve displacement and fluorescence resonance energy transfer effects, which can influence signal interpretation depending on dye ratios a

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. N Matsubara, et al. In vitro antibacterial activity of cefoperazone (T-1551), a new semisynthetic cephalosporin. Antimicrob Agents Chemother. 1979 Dec;16(6):731-5. [Content Brief]

[2]. Pedro H.Di Rocco, et al. Aerosol treatment with cefoperazone or gentamicin protects granulocytopenic mice from acute Pseudomonas aeruginosa pneumonia. European Journal of Pharmaceutical Sciences Volume 1, Issue 6, June 1994, Pages 285-289.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Cefoperazone dihydrate

7 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (7)
Protocols
Purity & Documentation
References

1/16
1/16

Cefoperazone dihydrate purchased from MedChemExpress. Usage Cited in: Carbohydr Polym. 2024 Jan 1:323:121379. [Abstract]

Customer Validation
According to the results, BC-CEF (Cefoperazone) had a loading quantity that was much higher than BC-CEF/Na.
1/16

Cefoperazone dihydrate purchased from MedChemExpress. Usage Cited in: Carbohydr Polym. 2024 Jan 1:323:121379. [Abstract]

Customer Validation
The drug release profiles of CEF (Cefoperazone) and CEF/Na from membranes in PBS.
1/16

Cefoperazone dihydrate purchased from MedChemExpress. Usage Cited in: Carbohydr Polym. 2024 Jan 1:323:121379. [Abstract]

Customer Validation
The antibacterial effectiveness of the BC-CEF (Cefoperazone) and BC-CEF/Na membranes against S. aureus and E. coli was very high.
1/16

Cefoperazone dihydrate purchased from MedChemExpress. Usage Cited in: J Antibiot (Tokyo). 2023 Apr;76(4):225-235. [Abstract]

Customer Validation
Susceptibility patterns of E. coli isolates (n = 140) towards different β-Lactams singly and in combination with β-Lactamase inhibitors (CFP Cefoperazone, CAZ Ceftazidime, FEP Cefepime).

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Cefoperazone dihydrate

Publications Citing Use of MedChemExpress (MCE) Cefoperazone dihydrate

All Antibiotic Isoforms