Cat. No.: HY-B0210A

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Cefoperazone sodium salt

(Synonyms: CP 52640-2)

7 Cited Publications

Customer Review

Based on 7 publication(s) in Google Scholar

Cefoperazone sodium salt (CP 52640-2), a semisynthetic cephalosporin, has a broad spectrum of antibacterial activity.

For research use only. We do not sell to patients.

Purity: 98.44%
CAS No.: 62893-20-3
Formula: C₂₅H₂₆N₉NaO₈S₂
Molecular Weight:667.65

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Cefoperazone sodium salt Chemical Structure

CAS No.: 62893-20-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (7)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cefoperazone sodium salt (CP 52640-2), a semisynthetic cephalosporin, has a broad spectrum of antibacterial activity^[1].

IC₅₀ & Target

β-lactam

All Antibiotic Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>100 μM Compound: 4a	Cytotoxicity against human A549 cells after 72 hrs by Alamar Blue assay Cytotoxicity against human A549 cells after 72 hrs by Alamar Blue assay	[PMID: 18752870]
MCF7	IC₅₀	>100 μM Compound: 4a	Cytotoxicity against human MCF7 cells after 72 hrs by Alamar Blue assay Cytotoxicity against human MCF7 cells after 72 hrs by Alamar Blue assay	[PMID: 18752870]

In Vitro

Cefoperazone (Aerosol treatment, 60 μg/mL final concentration in lung homogenate) protects granulocytopenic mice from acute Pseudomonas aeruginosa pneumonia^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 62893-20-3
Appearance Solid
Molecular Weight 667.65
Formula C₂₅H₂₆N₉NaO₈S₂
Color White to off-white
SMILES

O=C(C(N12)=C(CSC3=NN=NN3C)CS[C@]2([H])[C@H](NC([C@H](NC(N4C(C(N(CC)CC4)=O)=O)=O)C5=CC=C(O)C=C5)=O)C1=O)O[Na]
Synonyms

CP 52640-2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (7)

All Bio/Physico-chemical AssayMicrobiological Assay

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Journal Impact Factor

Signal Transduct Target Ther

Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]

2025 Dec 15;10(1):406. PMID: 41392286
Carbohydr Polym

Preparation of bacterial cellulose-based antibacterial membranes with prolonged release of drugs: Emphasis on the chemical structure of drugs. [Abstract]

2024 Jan 1:323:121379. PMID: 37940275

Cefoperazone sodium salt purchased from MedChemExpress. Usage Cited in: Carbohydr Polym. 2024 Jan 1:323:121379. [Abstract]

According to the results, BC-CEF (Cefoperazone) had a loading quantity that was much higher than BC-CEF/Na.

Cefoperazone sodium salt purchased from MedChemExpress. Usage Cited in: Carbohydr Polym. 2024 Jan 1:323:121379. [Abstract]

The drug release profiles of CEF (Cefoperazone) and CEF/Na from membranes in PBS.

Cefoperazone sodium salt purchased from MedChemExpress. Usage Cited in: Carbohydr Polym. 2024 Jan 1:323:121379. [Abstract]

The antibacterial effectiveness of the BC-CEF (Cefoperazone) and BC-CEF/Na membranes against S. aureus and E. coli was very high.
Mol Med

Dexmedetomidine alleviates intestinal ischemia/reperfusion injury by modulating intestinal neuron autophagy and mitochondrial homeostasis via Nupr1 regulation. [Abstract]

2024 Nov 6;30(1):203. PMID: 39508252
Virulence

Antibacterial efficacy and mechanism of the novel antimicrobial peptide lachnospirin-1 against Acinetobacter baumannii. [Abstract]

2026 Dec 31;17(1):2646808. PMID: 41838520
Ther Adv Med Oncol

Repurposing of ivacaftor shows potential to treat ROR1 expressing high-grade serous ovarian cancer. [Abstract]

2026 Jan 2:18:17588359251409010. PMID: 41487693
Toxicol Appl Pharmacol

Role of microbial microbes in arsenic bioaccumulation and biotransformation in mice. [Abstract]

2023 Apr 1:464:116447. PMID: 36889513
J Antibiot (Tokyo)

Impact of short chain fatty acids (SCFAs) on antimicrobial activity of new β-lactam/β-lactamase inhibitor combinations and on virulence of Escherichia coli isolates. [Abstract]

2023 Apr;76(4):225-235. PMID: 36726014

Cefoperazone sodium salt purchased from MedChemExpress. Usage Cited in: J Antibiot (Tokyo). 2023 Apr;76(4):225-235. [Abstract]

Susceptibility patterns of E. coli isolates (n = 140) towards different β-Lactams singly and in combination with β-Lactamase inhibitors (CFP Cefoperazone, CAZ Ceftazidime, FEP Cefepime).

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (187.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 60 mg/mL (89.87 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.4978 mL

7.4890 mL

14.9779 mL

5 mM

0.2996 mL

1.4978 mL

2.9956 mL

10 mM

0.1498 mL

0.7489 mL

1.4978 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (3.12 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (3.12 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (3.12 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (149.78 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. N Matsubara, et al. In vitro antibacterial activity of cefoperazone (T-1551), a new semisynthetic cephalosporin. Antimicrob Agents Chemother. 1979 Dec;16(6):731-5. [Content Brief]

[2]. Pedro H.Di Rocco, et al. Aerosol treatment with cefoperazone or gentamicin protects granulocytopenic mice from acute Pseudomonas aeruginosa pneumonia. European Journal of Pharmaceutical Sciences Volume 1, Issue 6, June 1994, Pages 285-289.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	1.4978 mL	7.4890 mL	14.9779 mL	37.4448 mL
	5 mM	0.2996 mL	1.4978 mL	2.9956 mL	7.4890 mL
	10 mM	0.1498 mL	0.7489 mL	1.4978 mL	3.7445 mL
	15 mM	0.0999 mL	0.4993 mL	0.9985 mL	2.4963 mL
	20 mM	0.0749 mL	0.3744 mL	0.7489 mL	1.8722 mL
	25 mM	0.0599 mL	0.2996 mL	0.5991 mL	1.4978 mL
	30 mM	0.0499 mL	0.2496 mL	0.4993 mL	1.2482 mL
	40 mM	0.0374 mL	0.1872 mL	0.3744 mL	0.9361 mL
	50 mM	0.0300 mL	0.1498 mL	0.2996 mL	0.7489 mL
	60 mM	0.0250 mL	0.1248 mL	0.2496 mL	0.6241 mL
	80 mM	0.0187 mL	0.0936 mL	0.1872 mL	0.4681 mL
DMSO	100 mM	0.0150 mL	0.0749 mL	0.1498 mL	0.3744 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cefoperazone sodium salt

7 Cited Publications

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