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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
247 Results for "
translational diffusion coefficient
" in MedChemExpress (MCE) Product Catalog:
Products (247)
247 Results for "translational diffusion coefficient" in MCE Product Catalog:
Art. -Nr.: HY-L226
3,693 compounds
Post-translational modifications (PTMs) refer to chemical modifications that occur on amino acid residues of proteins after translation, involving the addition or removal of specific functional groups. These modifications regulate protein activity, localization, folding, and interactions with other biomolecules. By influencing protein function, PTMs play a crucial role in various pathophysiological processes. Common types of PTMs include protein phosphorylation, methylation, acetylation, ubiquitination, glycosylation, and more.
MCE offers 3,693 PTM-targeting compounds, which can be used for drug screening in cancer, neurodegenerative diseases, metabolic disorders, etc.
Art. -Nr.: HY-D3047I
Target:
Forschungsgebiete:
Rhodamine B-Dextran (chloride) (MW 500000) is a Rhodamine B (HY-Y0016)-labeled dextran with a molecular weight of 500000. Rhodamine B-Dextran (chloride) (MW 500000) is a fluorescent dye used to track the diffusion of macromolecules in ex vivo human skin. Rhodamine B-Dextran (chloride) (MW 500000) is delivered to skin layers via the Nanopatch microneedle array, which physically disrupts the stratum corneum and dermal-epidermal junction barriers to deposit the dye directly into epidermal and dermal regions; fluorescence is detected via multiphoton microscopy, and fluorescence intensity is assumed to be roughly proportional to dye concentration .
Art. -Nr.: HY-121235R
CAS. Nr.: 17737-65-4
Synonyms: SCH-10304 (Standard)
Forschungsgebiete:
Clonixin (SCH-10304) (Standard) is the analytical standard of Clonixin. This product is intended for research and analytical applications. Clonixin is an orally active non-steroidal anti-inflammatory agent (NSAID) that inhibits COX synthesis. Clonixin acts as a voltage-gated L-type calcium channel blocker, exerts vasodilatory effects by antagonizing Ca 2+ in vascular smooth muscle. Clonixin inhibits TGF-β, reduces lung coefficient, immune cell infiltration level, oxidative stress response, airway resistance, hydroxyproline content and collagen deposition. Clonixin can be used in research related to inflammation such as idiopathic pulmonary fibrosis and moderate to severe pain .
Art. -Nr.: HY-D0925C
CAS. Nr.: 910482-46-1
Synonyms: Cyanine5.5 NHS ester potassium
Target:
Forschungsgebiete:
Cy5.5-SE (Cyanine5.5 NHS ester) potassium is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance .
Art. -Nr.: HY-DY1062
CAS. Nr.: 210892-23-2
Target:
Forschungsgebiete:
Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Cy5.5 (solution) is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis . CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance .
Solvent and concentration: DMSO: 10 mM
Solvent and concentration: DMSO: 10 mM
Art. -Nr.: HY-DY1067
CAS. Nr.: 1437796-65-0
Synonyms: Cyanine5 maleimide (solution)
Solvent and concentration: DMSO: 10 mM
Art. -Nr.: HY-DY1069
CAS. Nr.: 1393363-07-9
Solvent and concentration: DMSO: 10 mM
Art. -Nr.: HY-DY1119
CAS. Nr.: 186205-37-8
Target:
Forschungsgebiete:
Cy2 Iodide (solution) is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis . CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance .
Solvent and concentration: DMSO: 10 mM
Solvent and concentration: DMSO: 10 mM
Art. -Nr.: HY-128443R
CAS. Nr.: 122-19-0
Synonyms: BDMSAC (Standard)
Forschungsgebiete:
Benzyldimethylstearylammonium chloride (Standard) (BDMSAC (Standard)) is the analytical standard of Benzyldimethylstearylammonium chloride (HY-128443). This product is intended for research and analytical applications. Benzyldimethylstearylammonium chloride is a quaternary ammonium cationic surfactant and a mixed-type corrosion inhibitor. Benzyldimethylstearylammonium chloride adsorbs onto the surface of cold-rolled steel through a combined effect of physisorption and chemisorption, forming a hydrophobic protective barrier that blocks active sites and restricts the diffusion of corrosive media, while simultaneously inhibiting the anodic iron dissolution reaction and the cathodic hydrogen evolution reaction, and reducing the corrosion rate in acidic media. Benzyldimethylstearylammonium chloride is used in research related to various fields such as fungicides, wastewater treatment, and detergents .
Art. -Nr.: HY-W585827
CAS. Nr.: 497-04-1
Synonyms: 2-MCPD
Target:
Forschungsgebiete:
2-Chloro-1,3-propanediol (2-MCPD) is a pharmaceutical intermediate. 2-Chloro-1,3-propanediol is a common glycerol-derived chemical intermediate and also a food processing contaminant. 2-Chloro-1,3-propanediol can cross the intestinal barrier model via paracellular diffusion. 2-Chloro-1,3-propanediol induces renal and testicular toxicity in animal models. 2-Chloro-1,3-propanediol can be used in research related to organic synthesis .
Art. -Nr.: HY-110143R
CAS. Nr.: 1181081-71-9
Target:
Forschungsgebiete:
CLP257 (Standard) is the analytical standard of CLP257 (HY-110143). This product is intended for research and analytical applications. CLP257 is a selective K+-Cl cotransporter KCC2 activator with an EC50 of 616 nM. CLP257 is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 restores impaired Cl transport in neurons with diminished KCC2 activity. CLP257 alleviates hypersensitivity in rats with neuropathic pain. CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally .
Art. -Nr.: HY-111753AR
CAS. Nr.: 2749300-35-2
Target:
Forschungsgebiete:
WDR5-IN-4 TFA (Standard) is the analytical standard of WDR5-IN-4 (TFA) (HY-111753A). This product is intended for research and analytical applications. WDR5-IN-4 TFA (Compound C6) is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a Kd of 0.1 nM. WDR5-IN-4 TFA displaces WDR5 from chromatin and decreases the expression of associated genes, causing translational inhibition, nucleolar stress. Anti-cancer activity .
Art. -Nr.: HY-150286A
CAS. Nr.: 2715974-36-8
Target:
Forschungsgebiete:
(R)-SM875 is a cellular prion protein (PrP) degrader with an IC50 of 3 μM in HEK293 cells. (R)-SM875 interacts with PrP folding intermediates, binds to a binding pocket unique to FI-PrP, inhibits PrP C maturation, blocks prion replication, and induces cytotoxicity, autophagy, PrP C aggregation, as well as lysosome-dependent autophagy-mediated post-translational degradation of PrP C, without altering the mRNA level of PrP C. (R)-SM875 can be used in research related to prion diseases .
Art. -Nr.: HY-163105
CAS. Nr.: 3072778-26-5
Target:
Forschungsgebiete:
Tubulin/NEDDylation-IN-1 (compound C11) is a dual inhibitor of tubulin (Microtubule/Tubulin)-NEDDylation (IC50 for tubulin=2.40 μM), which has strong anti-proliferative activity. Neddylation is a protein post-translational modification that covalently tags the ubiquitin-like protein NEDD8 to target proteins. Tubulin/NEDDylation-IN-1 forms hydrogen bonds with residues of tubulin and E1 NEDD8 activating enzyme (NAE) through methoxy and dithiocarbamate groups and inhibits NEDDylation and microtubulin in an ATP-dependent manner. tube polymerization .
Art. -Nr.: HY-W612338
CAS. Nr.: 2553-17-5
Synonyms: 9-ONA
Target:
Art. -Nr.: HY-D1429
CAS. Nr.: 287715-95-1
Target:
Forschungsgebiete:
ER-Tracker dye is a derivative of BODIPY series dyes coupled with Glibenclamide (HY-15206), highly selective binding to the endoplasmic reticulum, non-toxic to cells at low concentrations, this type of dye is an environmentally sensitive probe, and formaldehyde treatment can still retain part of the fluorescence, with high fluorescence life, good extinction coefficient and other characteristics. Glibenclamide is an atp-dependent K + channel blocker (Kir6, KATP) and CFTR Cl-channel blocker that binds in the endoplasmic reticulum. ER-Tracker is not suitable for staining fixed cells. Staining followed by fixation is possible, but cells fixed with aldehydes will only retain partial fluorescence (Ex/Em = 374/ 430-640 nm) .
Art. -Nr.: HY-DY1074
CAS. Nr.: 287715-95-1
Target:
Forschungsgebiete:
ER-Tracker dye is a derivative of BODIPY series dyes coupled with Glibenclamide (HY-15206) , highly selective binding to the endoplasmic reticulum, non-toxic to cells at low concentrations, this type of dye is an environmentally sensitive probe, and formaldehyde treatment can still retain part of the fluorescence, with high fluorescence life, good extinction coefficient and other characteristics. Glibenclamide is an atp-dependent K + channel blocker (Kir6, KATP) and CFTR Cl-channel blocker that binds in the endoplasmic reticulum. ER-Tracker is not suitable for staining fixed cells. Staining followed by fixation is possible, but cells fixed with aldehydes will only retain partial fluorescence .
Solvent and concentration: DMSO: 1 mM
Solvent and concentration: DMSO: 1 mM
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
