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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
280 Results for "
immune function
" in MedChemExpress (MCE) Product Catalog:
Products (280)
280 Results for "immune function" in MCE Product Catalog:
Cat. No.: HY-N1461R
CAS No.: 17238-05-0
Synonyms: (±)-Dihydrodaidzein (Standard)
Cat. No.: HY-P10352
CAS No.: 111745-56-3
Cat. No.: HY-P991898
Synonyms: RD126
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Cat. No.: HY-P990237
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Synonyms: Amethopterin monohydrate; CL14377 monohydrate; WR19039 monohydrate
Methotrexate monohydrate (Amethopterin monohydrate; CL14377 monohydrate; WR19039 monohydrate) is an orally active antifolate (Antifolate). Methotrexate monohydrate inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate monohydrate promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate monohydrate induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate monohydrate is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer .
Cat. No.: HY-150298R
CAS No.: 2226636-04-8
Synonyms: CPI-818 (Standard)
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Soquelitinib (Standard) is the analytical standard of Soquelitinib (HY-150298). This product is intended for research and analytical applications. Soquelitinib (CPI-818) is an orally active and highly selective covalent interleuKin-2-inducible Kinase (ITK) inhibitor. Soquelitinib is active in six different models of T cell-mediated inflammatory and immune disease, including acute and chronic asthma, pulmonary fibrosis, systemic sclerosis (scleroderma), psoriasis, and acute graft versus host disease with Th2 cytoKine product inhibition. Soquelitinib increases tumor infiltration of normal CD8 + cells that possess enhanced T effector function .
Cat. No.: HY-184535
CAS No.: 3008320-14-4
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PDIC-DPC is a HMGA1 inhibitor and lung-targeting agent. PDIC-DPC upregulates STING expression and enhances STING-mediated immune signaling. PDIC-DPC inhibits the TGFβ-Smad pathway and activates AMPK. PDIC-DPC forms nanocomplexes with fibrinogen β chain and vitronectin, and achieves lung-specific accumulation by binding to pulmonary endothelial receptors. PDIC-DPC reverses established pulmonary fibrosis, reduces collagen deposition, restores alveolar structure, improves pulmonary function, and inhibits in situ ESCC growth. PDIC-DPC can be used for the research of esophageal squamous cell carcinoma and idiopathic pulmonary fibrosis .
Cat. No.: HY-187712
CAS No.: 3056281-16-1
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PD-1/PD-L1-IN-68 is a PD-L1 inhibitor based on a tetrahydroisoquinoline scaffold, with a KD of 21.31 μM for binding to hPD-L1, and it blocks the PD-1/PD-L1 interaction. PD-1/PD-L1-IN-68 restores T cell immune function, thereby promoting the death of PD-L1 + cancer cells. PD-1/PD-L1-IN-68 can be used in studies related to liver cancer .
Cat. No.: HY-N2192R
CAS No.: 23445-00-3
Cat. No.: HY-P10424
CAS No.: 2378606-21-2
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Cat. No.: HY-P990236
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Cat. No.: HY-P991455
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Cat. No.: HY-P992163
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Cat. No.: HY-N0534R
CAS No.: 64820-99-1
Category:
other families Flavonoids Flavones Phenols Polyphenols Plants
Cat. No.: HY-121151
CAS No.: 60388-53-6
Synonyms: (±)-Amethopterin; (±)-CL14377; (±)-WR19039
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(±)-Methotrexate ((±)-Amethopterin; (±)-CL14377; (±)-WR19039) is the racemate of Methotrexate (HY-14519). Methotrexate is an orally active antifolate (Antifolate). Methotrexate inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer .
Cat. No.: HY-19307
CAS No.: 205678-31-5
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Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
SB-273005 is an orally active non-peptide αvβ3 integrin antagonist with Ki values of 1.2 nM and 0.3 nM for αvβ3 and αvβ5, respectively. SB-273005 blocks the binding of integrins to the RGD sequence in the extracellular matrix. SB-273005 inhibits Rictor phosphorylation and reduces IL-10 secretion. SB-273005 inhibits inflammation, prevents bone loss, regulates vascular smooth muscle function, and reverses pregnancy-induced immune deviation. SB-273005 can be used in the study of rheumatoid arthritis, osteoporosis, and aneurysms. .
Synonyms: (-)-Eburnamonine (Standard); (-)-Vincamone (Standard)
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Cat. No.: HY-P10352A
Cat. No.: HY-P99138
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Cat. No.: HY-P99152
CAS No.: 140608-64-6
Synonyms: Muromanab-CD3
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
