Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
97 Results for "
CYP1A2
" in MedChemExpress (MCE) Product Catalog:
Products (97)
97 Results for "CYP1A2" in MCE Product Catalog:
Synonyms: PTC857
Research Areas:
Utreloxastat (PTC857) is an orally active and blood-brain barrier-permeable 15-lipooxygenase inhibitor. Utreloxastat is a weak inhibitor of CYP1A2 and 2B6 with an IC50 of >5.3 μM. Utreloxastat reduces oxidative stress and inhibits the consumption of reduced glutathione and ferroptosis. Utreloxastat can be used in the study of neurodegenerative diseases characterized by high levels of oxidative stress and mitochondrial pathology, such as amyotrophic lateral sclerosisc .
Cat. No.: HY-B0476S
CAS No.: 69323-74-6
Synonyms: Acetophenetidin-d5
Cat. No.: HY-Y0110S1
CAS No.: 78832-54-9
Target:
Research Areas:
Phenacetin (Standard) is the analytical standard of Phenacetin. This product is intended for research and analytical applications. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats .
Cat. No.: HY-W267897
CAS No.: 220001-53-6
Synonyms: 7-BFC
Target:
Research Areas:
7-Benzyloxy-4-(trifluoromethyl) coumarin (7-BFC) is a coumarin-based fluorescent substrate. 7-Benzyloxy-4-(trifluoromethyl) coumarin serves as a substrate for cDNA-expressed CYP1A2 and CYP3A4, and is metabolized into 7-hydroxy-4-trifluoromethylcoumarin (HFC). 7-Benzyloxy-4-(trifluoromethyl) coumarin supports metabolic studies of cytochrome P450 subtypes via its fluorescent metabolite .
Cat. No.: HY-W015998S
CAS No.: 773005-79-1
Cat. No.: HY-W045990
CAS No.: 582-16-1
Target:
Cat. No.: HY-116780A
CAS No.: 1225-65-6
Target:
Research Areas:
Prothipendyl hydrochloride is a tricyclic azaphenothiazine neuroleptic agent. Prothipendyl hydrochloride is a substrate of the CYP isozymes CYP1A2, CYP2D6, CYP2C19 and CYP3A4. Prothipendyl hydrochloride has sedating and psychomotorically damping effects. Prothipendyl hydrochloride can be used for psychomotoric agitation, sleep disorder and anxiety research .
Cat. No.: HY-N8382
CAS No.: 13164-03-9
Target:
Cat. No.: HY-RS03442
Target:
Research Areas:
CYP1A2 Human Pre-designed siRNA Set A contains three designed siRNAs for CYP1A2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-W015697
CAS No.: 612-58-8
Target:
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
3-Methylquinoline is a selective cytochrome P450 (CYP1A2) inhibitor with an IC50 of 13 μM. 3-Methylquinoline can reduce the metabolic clearance of CYP1A2 substrate drugs. 3-Methylquinoline can inhibit the activation of carcinogenic precursors .
Cat. No.: HY-W275481
CAS No.: 2305-05-7
Target:
Research Areas:
γ-Dodecanolactone is a γ-lactone compound. γ-Dodecanolactone exhibits inhibitory activity against CYP1A2 with an IC50 value of 58 µM and a pIC50 value of 4.24. γ-Dodecanolactone can be used in the research of diseases related to the CYP1A2 enzyme .
Cat. No.: HY-W777979
CAS No.: 38210-27-4
Category:
Polygala fruticosa P.J.Bergius Polygalaceae Extract Coumarins Hydroleaceae Extract Phenylpropanoids Plants
Target:
Cat. No.: HY-N3090
CAS No.: 46992-81-8
Target:
Cat. No.: HY-B0352A
CAS No.: 61337-87-9
Synonyms: (S)-Org3770; (S)-6-Azamianserin
Target:
Research Areas:
(S)-Mirtazapine ((S)-Org3770) is a S(+)-enantiomer of Mirtazapine with pronociceptive properties in an animal model of acute thermal nociception. (S)-Mirtazapine is a stereoselective 5-HT2 receptor antagonist. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2 .
Cat. No.: HY-N1882
CAS No.: 18110-87-7
Category:
Alkaloids Simaroubaceae Extract Pyridine Alkaloids Metabolic Disease Plants Disease Research Fields Indole Alkaloids
Target:
Cat. No.: HY-B0476S1
CAS No.: 72156-72-0
Synonyms: (S)-6-Desmethyl Naproxen
Target:
Research Areas:
(S)-6-O-Desmethylnaproxen ((S)-6-Desmethyl Naproxen) is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (+)-naproxen ((S)-naproxen). (S)-6-O-Desmethylnaproxen is formed from (S)-naproxen by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP2C9.
Cat. No.: HY-155732
CAS No.: 3032452-65-3
NPD-2975 (compound 30) is an orally active antitrypanosomal agent, against Human African Trypanosomiasis (HAT). NPD-2975 has low toxicity potential against human MRC-5 lung fibroblasts, and acute mouse model of T. b. brucei infection. NPD-2975 shows acceptable metabolic stability, inhibits T. b. brucei with IC500 of 70 nM in vitro. NPD-2975 also inhibits CYP enzymes resulted in IC50 values of 0.16 and 0.42 μM against CYP1A2 and CYP2C19, respectively .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
